Results 41 to 50 of about 5,741,122 (252)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Journal of the Mechanical Behavior of Materials, 2023 A number of destructive and non-destructive tests were conducted on rock samples collected from various zones in northern Iraq. So far, for Iraqi rocks, few studies have correlated Schmidt hammer rebound (R) with both unconfined compressive strength (UCS)
Fadhil Amjad Ibrahim +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A Novel Intelligent Rebound Hammer System Based on Internet of Things
Micromachines, 2023 In order to improve the test efficiency of concrete strength and ensure measured data reliability, we present a novel intelligent rebound hammer system which is based on the Internet of Things (IoT) and speech recognition technology.
Zongqiang Pang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Supply constraints on rebound effects of increased energy efficiency : negative multiplier and disinvestment effects [PDF]
, 2010 Policies that aim to use increased energy efficiency to reduce energy use may not achieve the desired results due to the likelihood of rebound effects.
Turner, Karen +3 more
core +3 more sources
Alexandria Engineering Journal, 2012 This study aims to investigate the relationships between Schmidt hardness rebound number (RN) and ultrasonic pulse velocity (UPV) versus compressive strength (fc) of stones and bricks.
Ali Abd Elhakam Aliabdo +1 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Mechanical properties of re-packed reinforced Earth embankment during service stage
Journal of Asian Architecture and Building Engineering, 2022 Problems of large settlements and uneven settlements on the road always happen during service stage. Reinforced embankments can reduce these problems. But currently the study on the mechanical properties of reinforced embankments during service stage are
Hou Yujie +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source