Results 51 to 60 of about 53,348 (267)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mechanical properties of re-packed reinforced Earth embankment during service stage

Journal of Asian Architecture and Building Engineering, 2022
Problems of large settlements and uneven settlements on the road always happen during service stage. Reinforced embankments can reduce these problems. But currently the study on the mechanical properties of reinforced embankments during service stage are
Hou Yujie, Wang Bo, Huang Liang, He Weili, Zhu Jiahua, Wang Junjie   +5 more
doaj   +1 more source

A Study to Establish Correlation Between Rebound Value and Compressive Strength of Concrete Using Materials Available Locally in Nagpur

International Journal of Research in Advent Technology, 2021
This study has been taken to investigate the exact rebound-strength relationship of different grades of concrete, as the curves generated for traditional hammers are outdated. Using the material available in the Nagpur region, cube specimens were cast and tested as per IS:516-1959 [1]. Several sets were cast with varying cement contents, decided by mix
Aman Raj, Pramod Deshmukh, Pradeepa. S
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Application of lichenometry and residual strength test for age estimation of Holocene moraines in the Suntar-Khayata Mountains

Лëд и снег, 2015
Residual strength and diameters of lichen Rhizocarpon sp. were measured on different elements of the Late Holocene glacial-cryogenic morphosculpture of frontal parts of glaciers № 29 and 31 in the Suntar-Khayat Range. All in all, 180 lichenometric sites (
A. A. Galanin, V. M. Lytkin, B. A. Shishkov   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Understanding the rebound surface hardness of concrete

Journal of Civil Engineering and Management, 2015
Surface hardness testing of materials can be considered as the oldest method to get information about strength related material properties. In recent decades the rebound hammer has been the most popular surface hardness testing device for concrete ...
Katalin Szilágyi, Adorján Borosnyói, István Zsigovics   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Efficacy of dexamethasone or clonidine as adjuvants in interscalene brachial plexus block for preventing rebound pain after shoulder surgery: a randomized clinical trial

Brazilian Journal of Anesthesiology
Background: Rebound pain is believed to involve both nociceptive pain due to insufficient analgesia and hyperalgesia induced by regional anesthesia. Adjuvant's addition could prevent rebound pain.
Layana Vieira Nobre, Leonardo Henrique Cunha Ferraro, Juscelino Afonso de Oliveira Júnior, Vitória Luiza Locatelli Winkeler, Luis Flávio França Vinhosa Muniz, Hiago Parreão Braga, Plínio da Cunha Leal   +6 more
doaj   +1 more source