Results 71 to 80 of about 194,996 (299)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Application of lichenometry and residual strength test for age estimation of Holocene moraines in the Suntar-Khayata Mountains

Лëд и снег, 2015
Residual strength and diameters of lichen Rhizocarpon sp. were measured on different elements of the Late Holocene glacial-cryogenic morphosculpture of frontal parts of glaciers № 29 and 31 in the Suntar-Khayat Range. All in all, 180 lichenometric sites (
A. A. Galanin, V. M. Lytkin, B. A. Shishkov   +2 more
doaj   +1 more source

Numerical analysis of fluid-material coupled method on propagation of pressure and stress waves during non-spherical bubble collapse

Nihon Kikai Gakkai ronbunshu, 2021
When analyzing cavitation erosion, it is necessary to grasp the stress state inside a material due to the bubble collapse process. In this study, the behavior of a vapor bubble collapse and the stress distribution inside the material due to the bubble ...
Hirotoshi SASAKI, Susumu ENDO, Yuka IGA
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Understanding the rebound surface hardness of concrete

Journal of Civil Engineering and Management, 2015
Surface hardness testing of materials can be considered as the oldest method to get information about strength related material properties. In recent decades the rebound hammer has been the most popular surface hardness testing device for concrete ...
Katalin Szilágyi, Adorján Borosnyói, István Zsigovics   +2 more
doaj   +1 more source

UKERC Review of evidence for the rebound effect: Technical report 5: Energy, productivity and economic growth studies [PDF]

, 2007
This report forms part of the TPA’s assessment of evidence for a rebound effect from improved energy efficiency. Technical Report 5 focuses upon the relationship between energy, productivity and economic growth and examines the claim that improved energy
Dimitropoulos, John, Sorrell, Steve
core   +1 more source

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals. [PDF]

, 2019
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption.
Bale, Michael J, Busch, Michael P, Cox, Bryan, Deeks, Steven G, Hoh, Rebecca, Kearney, Mary F, Kulpa, Deanna A, Lackman-Smith, Carol, Maldarelli, Frank, Ptak, Roger G, Stone, Mars, Subramanian, Krupa, Wiegand, Ann, Wonderlich, Elizabeth R   +13 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Efficacy of dexamethasone or clonidine as adjuvants in interscalene brachial plexus block for preventing rebound pain after shoulder surgery: a randomized clinical trial

Brazilian Journal of Anesthesiology
Background: Rebound pain is believed to involve both nociceptive pain due to insufficient analgesia and hyperalgesia induced by regional anesthesia. Adjuvant's addition could prevent rebound pain.
Layana Vieira Nobre, Leonardo Henrique Cunha Ferraro, Juscelino Afonso de Oliveira Júnior, Vitória Luiza Locatelli Winkeler, Luis Flávio França Vinhosa Muniz, Hiago Parreão Braga, Plínio da Cunha Leal   +6 more
doaj   +1 more source

Estimating the Compressive Strength of High-Strength Concrete Using Surface Rebound Value and Ultrasonic Velocity

Journal of the Korea institute for structural maintenance and inspection, 2016
Abstract: The authors performed the experimental work to propose the strength prediction equation for high strength concrete based on thenon-destructive test methods. The concrete specimens that the range of design compressive strength was 40~80 MPa was produced i n laboratory, and then tested rebound test and ultrasonic velocity methods and also ...
Min Wook Kim, Hongseob Oh, Kwang Chin Oh
openaire   +2 more sources