The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
From the help desk: Comparing areas under receiver operating characteristic curves from two or more probit or logit models [PDF]
Occasionally, there is a need to compare the predictive accuracy of several fitted logit (logistic) or probit models by comparing the areas under the corresponding receiver operating characteristic (ROC) curves.
Mario A. Cleves
core +1 more source
A Linear Regression Framework for Receiver Operating Characteristic(ROC) Curve Analysis [PDF]
, 2005 In the field of medical diagnostic testing, the receiver operating characteristics(ROC) curve has long been used as a standard statistical tool to assess the accuracy of tests that yield continuous results. Although previous research in this area focused
Pepe, Margaret S., Zhang, Zheng
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Health and Income Poverty in Ireland, 2003-2006 [PDF]
Recent advances in the measurement of bi-dimensional poverty are applied to a measure of poverty which incorporates income and health poverty. The correlation between income and poverty is examined using the Receiver Operating Characteristics curve ...
David Madden
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
AUK: a simple alternative to the AUC [PDF]
, 2010 The area under Receiver Operating Characteristic (ROC) curve, also known as the AUC-index, is commonly used for ranking the performance of data mining models. The AUC has many merits, such as objectivity and ease of interpretation.
Ben-David, A. (Arie) +2 more
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Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source
3D ROC Histogram: A New ROC Analysis Tool Incorporating Information on Instances
IEEE Access, 2019 While Receiver Operator Characteristic (ROC) curves have been a standard tool in the design and evaluation of binary classification problems, they have sometimes been blamed for ignoring some vital information in the evaluation process, such as predicted
Rui Guo, Xuanjing Shen, Xiaoli Zhang
doaj +1 more source
An Improved Method for Bandwidth Selection when Estimating ROC Curves [PDF]
The receiver operating characteristic (ROC) curve is used to describe the performance of a diagnostic test which classifies observations into two groups.
Peter Hall, Rob J. Hyndman
core