Results 271 to 280 of about 602,046 (339)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Detecting bias in algorithms used to disseminate information in social networks and mitigating it using multiobjective optimization. [PDF]

PNAS Nexus
Sekara V, Dotu I, Cebrian M, Moro E, Garcia Herranz M.   +4 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Measuring naturalistic speech comprehension in real time. [PDF]

Behav Res Methods
Ergin I, Kries J, Gupta S, Papworth Burrel M, Gwilliams L.   +4 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Confidence and competence of recent veterinary graduates--is there a problem?

, 2003
Jeanne Löfstedt
openalex   +1 more source

HIV-1 infection recency among individuals newly diagnosed with HIV in Greater Gaborone, Botswana. [PDF]

AIDS
Moraka NO, Ralegoreng C, Lemogang GM, Makwakwa R, Pema MN, Mokgethi PT, Choga OT, Gobe I, Mokomane M, Maruapula D, Moutswi ST, Rabatoko L, Leteemane Q, Strachan-Amaro V, Sabone P, Mohammed T, Moyo S, Gaseitsiwe S.   +17 more
europepmc   +1 more source

Disentangling the developmental cascades between adolescent maltreatment and internalizing and externalizing problems: From between-person differences to within-person changes. [PDF]

J Res Adolesc
Lu Z.
europepmc   +1 more source

Indecision and recency-weighted evidence integration in non-clinical and clinical settings. [PDF]

Nat Hum Behav
Del Río M, Trudel N, Prabhu G, Hunt LT, Moutoussis M, Dolan RJ, Hauser TU.   +6 more
europepmc   +1 more source