Results 61 to 70 of about 17,143 (264)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Longitudinal evaluation of HIV-1 LAg incidence assay and proficiency panel stability for external quality assurance

Microbiology Spectrum
Accurate HIV incidence estimates are essential for monitoring epidemic trends and evaluating prevention efforts. The limiting antigen (LAg) avidity enzyme immunoassay is the most widely used method to classify recent versus long-term HIV infections.
Clara Di Germanio, Wes Rountree, Eduard Grebe, Mars Stone, Aditi Sanghavi, Brendan G. Balasko, Jahnavi Bhaskar, Patricia G. Villaflor, Paul M. Hargarten, Marek Poniewierski, Sylvester Hood, Cassandra G. Porth, Thomas N. Denny, Michael P. Busch   +13 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gestalt approach and cognitive fallacies: mitigating negative recency and positive recency

Cognitive Processing
Abstract This study examined whether Gestalt-based manipulations can reduce individual’s tendency to follow negative recency (NR) or positive recency (PR) by inducing their perception that events are not related. Two types of manipulation – grouping and closure – were introduced through a series of Coin Prediction Tasks.
Yeonho Choi, Kyungil Kim, Lisa K. Son
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Serial-Position Effects in Preference Construction: A Sensitivity Analysis of the Pairwise-Competition Model

Frontiers in Psychology, 2014
People have a stronger preference for options encountered earlier or later in a sequence than for options in the middle of the sequence. To account for these primacy and recency effects, Mantonakis, Rodero, Lesschaeve, and Hastie (2009) sketched a ...
Emina eCanic, Thorsten ePachur
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Memory strength and recency judgments [PDF]

Psychonomic Bulletin & Review, 2005
Two experiments were done to examine the effect of memory strength on numerical judgment of recency (JOR). In one experiment, the strong versus weak manipulation was defined by stimulus type (pictures vs. names); and in the other, it was defined by long versus short study durations of pictures. Two hypotheses were contrasted: (1) that strong items seem
openaire   +2 more sources