Results 171 to 180 of about 18,592,089 (281)

Critical reflections on post-pandemic dengue surveillance in Quezon city, Philippines. [PDF]

Trop Med Health
Rafique SM, Rana RUR, Asghar I, Liaquat T.   +3 more
europepmc   +1 more source

Recent Decisions [PDF]

, 1916

core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Balancing Efficacy and Toxicity in Salvage Brachytherapy and SBRT for Radio-Recurrent Prostate Cancer: Insights Beyond the UroGEC Review. [PDF]

Technol Cancer Res Treat
Bilski M, Fijuth J, Kuncman Ł.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

How recent is recent? Retrospective analysis of suspiciously timeless citations.

BMJ
Díez-Vidal A, Arribas JR.
europepmc   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti-Cancer Immunity Across the Lifespan. [PDF]

Immunol Rev
Bustillos CG, Peluso EM, Cha SL, Lechner MG, Su MA.   +4 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Recent-onset atrial fibrillation: challenges and opportunities. [PDF]

Eur Heart J
Svennberg E, Freedman B, Andrade JG, Anselmino M, Biton Y, Boriani G, Brandes A, Buckley CM, Cameron A, Clua-Espuny JL, Crijns HJGM, Diederichsen SZ, Doehner W, Dominguez H, Duncker D, Fauchier L, Glotzer T, Guo YS, Haeusler KG, Haim M, Healey JS, Hendriks JM, Hills MT, Hindricks G, Hobbs FDR, Johnson LS, Joung B, Kamel H, Kirchhof P, Lane DA, Levin LÅ, Lip GYH, Liu S, Lobban T, Macfarlane PW, Mairesse GH, Marcus GM, Noseworthy PA, Ntaios G, Orchard JJ, Passman R, Reidpath DD, Reiffel JA, Ribeiro AL, Rivard L, Sanders P, Sandhu RK, Schnabel RB, Siontis KC, Sposato LA, Stavrakis S, Steinhubl SR, Svendsen JH, Teh AW, Themistoclakis S, Tieleman RG, Camm AJ.   +56 more
europepmc   +1 more source