Results 101 to 110 of about 8,117,648 (243)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

What Justification? Pauline Reception and the Interpretation of Phld. 8.2

Religions
While studies of how Paul and the Pauline letters were received in early Christianity continue to appear at an ever-quickening rate, there are still corners of early Christian literature that remain underexplored with regard to Pauline reception.
Jonathon Lookadoo
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Spirit(s), Angels, and Virtues: The Reception of Isaiah 11:2–3a in Early Judaism

Verbum Vitae
This article examines the reception history of Isa 11:2–3a in Second Temple Judaism, as it relates to pneumatological perceptions and uses of the words for “spirit” in Hebrew and Greek (rûaḥ and pneuma).
Simon Johansson
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

(Re)contextualising audience receptions of reality TV [PDF]

, 2009
This paper seeks to recontextualise key findings from recent studies of reality TV audiences in light of insights drawn from across the wider field.
Michelle, Carolyn
core  

Images from the Ho Chi Minh City Alumni Reception, 2019

, 2019
Complete set of images from the Ho Chi Minh City Alumni Reception. Taken on Thursday 16th of May 2019 at the Pullman Saigon Centre, Ho Chi Minh City, Vietnam.
Swinburne University of Technology
core   +1 more source

Shakespeares värde och demokratins

Tidskrift för Litteraturvetenskap
The Values of Shakespeare and Democracy: Criticism and Politics in Sweden and the Nordic Countries, 1880–1960 This article examines how notions of Shakespeare’s literary value are related to aspects of democracy, especially in criticism on Shakespeare
Per Sivefors
doaj   +1 more source