Results 91 to 100 of about 394,846 (264)

Cardiovascular magnetic resonance‐estimated pulmonary capillary wedge pressure, congestion markers, and effect of empagliflozin in patients with heart failure with reduced ejection fraction and dysglycaemia (SUGAR‐DM‐HF)

European Journal of Heart Failure, EarlyView.
Abstract Aims A cardiovascular magnetic resonance (CMR) approach to non‐invasively estimate left ventricular (LV) filling pressure was recently developed and shown to correlate with invasively measured pulmonary capillary wedge pressure (PCWP). We examined the association between CMR‐estimated PCWP (CMR‐PCWP) and other imaging and biomarker measures of
Joanna Osmanska, Kieran F. Docherty, Colin Berry, Pardeep S. Jhund, Kenneth Mangion, Patrick B. Mark, John J.V. McMurray, Giles Roditi, Naveed Sattar, Mark C. Petrie, Ross T. Campbell, Matthew M.Y. Lee   +11 more
wiley   +1 more source

Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure

EMBO Molecular Medicine, 2017
Approaches to prolong responses to BRAF targeting drugs in melanoma patients are challenged by phenotype heterogeneity. Melanomas of a “MITF‐high” phenotype usually respond well to BRAF inhibitor therapy, but these melanomas also contain subpopulations ...
Michael P Smith, Emily J Rowling, Zsofia Miskolczi, Jennifer Ferguson, Loredana Spoerri, Nikolas K Haass, Olivia Sloss, Sophie McEntegart, Imanol Arozarena, Alex von Kriegsheim, Javier Rodriguez, Holly Brunton, Jivko Kmarashev, Mitchell P Levesque, Reinhard Dummer, Dennie T Frederick, Miles C Andrews, Zachary A Cooper, Keith T Flaherty, Jennifer A Wargo, Claudia Wellbrock   +20 more
doaj   +1 more source

Epigenetic silencing of the endothelin-B receptor gene in non-small cell lung cancer.

International Journal of Oncology, 2009
Endothelin-1 is overexpressed in several tumor types. Activation of the endothelin-A (ETA) receptor may promote cell growth, angiogenesis and invasion, and inhibits the apoptotic process, while activation of the endothelin-B (ETB) receptor may induce ...
Lucy Knight, J. Burrage, S. Bujac, C. Haggerty, A. Graham, N. Gibson, G. Ellison, J. Growcott, A. Brooks, A. Hughes, G. Xinarianos, G. Nikolaidis, J. Field, T. Liloglou   +13 more
semanticscholar   +1 more source

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

European Journal of Heart Failure, EarlyView.
Among high‐risk patients with T2D, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. ABSTRACT Aims The sodium–glucose cotransporter 2 inhibitor canagliflozin reduces the risk of heart failure (HF ...
Safia Chatur, Muthiah Vaduganathan, Robert A. Fletcher, Vlado Perkovic, Hiddo Heerspink, Clare Arnott, Carol Pollock, Kenneth W. Mahaffey, Bruce Neal, Meg Jardine, Scott D. Solomon, Brendon L. Neuen   +11 more
wiley   +1 more source

Modulation of pulmonary endothelial endothelin B receptor expression and signaling: implications for experimental hepatopulmonary syndrome.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2007
The hepatopulmonary syndrome (HPS) results from intrapulmonary vasodilation in the setting of cirrhosis and portal hypertension. In experimental HPS, pulmonary endothelial endothelin B (ET(B)) receptor overexpression and increased circulating endothelin ...
Liping Tang, Bao Luo, R. Patel, Y. Ling, Junlan Zhang, M. Fallon   +5 more
semanticscholar   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Gene expression of endothelin receptors in replaced rheumatic mitral stenotic valves Expressão gênica de receptores de endotelina em valvas mitrais reumáticas estenóticas substituídas

Brazilian Journal of Cardiovascular Surgery, 2012
OBJECTIVES: Rheumatic fever is a highly prevalent disease in Brazil, and it poses a major public health problem. It is the leading cause of acquired heart disease in childhood and adolescence.
Sydney Correia Leão, Fernanda Maria Silveira Souto, Ricardo Vieira da Costa, Thaisa de Fatima Almeida Rocha, Yolanda Galindo Pacheco, Tania Maria de Andrade Rodrigues   +5 more
doaj  

Cooperation of endothelin-1 signaling with melanosomes plays a role in developing and/or maintaining human skin hyperpigmentation

Biology Open, 2015
Skin hyperpigmentation is characterized by increased melanin synthesis and deposition that can cause significant psychosocial and psychological distress.
Daiki Murase, Akira Hachiya, Mamiko Kikuchi-Onoe, Rachel Fullenkamp, Atsushi Ohuchi, Takashi Kitahara, Shigeru Moriwaki, Tadashi Hase, Yoshinori Takema   +8 more
doaj   +1 more source

Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease.

Journal of Clinical Investigation, 1998
The spotting lethal rat, a naturally occurring rodent model of Hirschsprung disease, carries a deletion in the endothelin-B receptor (EDNRB) gene that abrogates expression of functional EDNRB receptors. Rats homozygous for this mutation (sl) exhibit coat
Cheryl E. Gariepy, S. Williams, James A. Richardson, Robert E. Hammer, Masashi Yanagisawa   +4 more
semanticscholar   +1 more source

Oligodendrogenesis in Evolution, Development and Adulthood

Glia, EarlyView.
Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu, Tianhao Gao, Jingwei Zhao, Huiliang Li   +3 more
wiley   +1 more source