Results 121 to 130 of about 394,846 (264)

Effects of combined treatment with zibotentan and dapagliflozin compared to dapagliflozin alone in patients with diabetic and non‐diabetic chronic kidney disease

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To evaluate whether type 2 diabetes status modifies the efficacy and safety of combining zibotentan (zibo), a selective endothelin receptor antagonist, and dapagliflozin (dapa) compared to placebo plus dapagliflozin in individuals with chronic kidney disease (CKD).
Victor Wasehuus   +7 more
wiley   +1 more source

Autoimmunity in MASLD: Focus on autoantibodies, anti‐apolipoprotein A1 IgG and G protein‐coupled receptors

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano   +3 more
wiley   +1 more source

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

open access: yesThe FEBS Journal, EarlyView.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert   +16 more
wiley   +1 more source

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment

open access: yesInternational Journal of Dermatology, EarlyView.
ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing   +3 more
wiley   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction

open access: yesCirculation: Heart Failure, 2016
M. Valero-Muñoz   +5 more
semanticscholar   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

open access: yesJournal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah   +8 more
wiley   +1 more source

Expression patterns of melanin‐related genes are linked to crypsis and conspicuousness in a pumpkin toadlet

open access: yesMolecular Ecology, EarlyView.
Abstract Colour signals play pivotal roles in different communication systems, and the evolution of these characters has been associated with behavioural ecology, integumentary production processes and perceptual mechanisms of the species involved. Here, we present the first insight into the molecular and histological basis of skin colour polymorphism ...
Juliane P. C. Monteiro   +7 more
wiley   +1 more source

The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation

open access: yesNeurogastroenterology &Motility, EarlyView.
Abstract Enteric glia are a heterogeneous population of peripheral glia within the enteric nervous system and play pivotal roles in gut homeostasis, tissue integrity, coordination of motility, and intestinal immune responses. Under physiological conditions, they communicate with enteric neurons to control intestinal motility.
Schneider Reiner   +4 more
wiley   +1 more source

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