Results 121 to 130 of about 42,145 (224)

Endothelin B Receptor Agonist SPI-1620 [PDF]

, 2020
openaire   +1 more source

Genetic Pigmentary Disorders: From Molecular Mechanisms to Clinical Manifestations

The Journal of Dermatology, Volume 53, Issue 2, Page 169-179, February 2026.
ABSTRACT Genetic pigmentary disorders represent a diverse group of genetic conditions characterized by alterations in melanin production and transport and melanocyte development, resulting from single‐gene pathological variants. These disorders encompass both hypopigmentary and hyperpigmentary phenotypes, affecting not only skin pigmentation but also ...
Ken Okamura, Tamio Suzuki
wiley   +1 more source

Endothelin as a Treatment Target in Cardiovascular Diseases: A Recent Step Forward. [PDF]

Rev Cardiovasc Med
Cole A, Kiełbowski K, Dach A, Szulc J, Bakinowska E, Pawlik A.   +5 more
europepmc   +1 more source

Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan, Eva Troyano‐Rodriguez, Jennifer Ihuoma, Sharon Negri, Rakesh Rudraboina, Aleksandra Kosmider, Shantipriya Awasthi, Priya Balasubramanian, Shannon Conley, Andriy Yabluchanskiy, Anna Csiszar, Zoltan Ungvari, Rafael de Cabo, Stefano Tarantini   +13 more
wiley   +1 more source

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo, Yi‐Chen Wu, Ji‐Min Li, Tz‐Chuen Ju, Tien‐Sheng Tseng   +4 more
wiley   +1 more source

Systemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case–Control Study

European Journal of Neurology, Volume 33, Issue 2, February 2026.
No significant differences were observed at any stage of the RCVS course between patients and controls. Systemic arterial stiffness, as assessed by PWV, remained normal and stable throughout the course of RCVS. No systemic complication has been detected during the RCVS course.
Pacôme Constant dit Beaufils, Laëtitia Barbin, Morgane Pere, Clarisse Colleu, Jérôme Connault, Cécile Préterre, Benoît Guillon, Solène de Gaalon   +7 more
wiley   +1 more source

Endogenous modulators in lung cancer. [PDF]

World J Clin Cases
Patel N, Patel V, Surani S.
europepmc   +1 more source

Environmental modulators of vascular physiology and inflammation

Experimental Physiology, Volume 111, Issue 2, Page 321-334, 1 February 2026.
Abstract Environmental factors play a crucial role in modulating vascular inflammation, contributing significantly to the development of atherosclerosis and cardiovascular disease. This review synthesizes current evidence on how various environmental exposures influence vascular function and inflammation, with a focus on pollutants such as particulate ...
Anusha N. Seneviratne, Anne Majumdar, Kalpana Surendranath, Mark R. Miller   +3 more
wiley   +1 more source

TERT expression in human prostate tissue reveals a potential molecular switch in benign prostatic hyperplasia progression. [PDF]

World J Urol
Xu Y, Hu S, Berger L, Nicola P, Weinhold P, Tamalunas A, Stief CG, Hennenberg M, Keller P.   +8 more
europepmc   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source