Results 151 to 160 of about 394,846 (264)
Altered Endothelin Receptor Expression in Idiopathic Male Infertility: A Potential Therapeutic Target. [PDF]
Weiten R+6 more
europepmc +1 more source
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani+5 more
wiley +1 more source
Endothelin-1 signaling in the kidney: recent advances and remaining gaps. [PDF]
Brooks AJ+2 more
europepmc +1 more source
Advancing antihypertensive drug development
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu+5 more
wiley +1 more source
Sotatercept: A Crosstalk Between Pathways and Activities in the Pulmonary Circulation and Blood. [PDF]
Madonna R, Ghelardoni S.
europepmc +1 more source
Effects of gestational intermittent hypoxia on maternal, fetal and offspring respiratory system. In black, effects in humans; in red, in vitro effects; in blue, effects in animal models. Summary Obstructive sleep apnea (OSA) is a common sleep disorder that is associated with a wide variety of health conditions, including cardiovascular, cerebrovascular,
Esther Valverde‐Pérez+4 more
wiley +1 more source
Endothelin-1 Participates in the Pathogenesis of Prurigo Nodularis by Promoting NGF Expression via Endothelial Receptor B in Epidermal Keratinocytes and Dorsal Root Ganglion Cells. [PDF]
Wong LS+4 more
europepmc +1 more source
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen+8 more
wiley +1 more source
Research trends and performance of endothelin A receptor antagonist in kidney care: a bibliometric analysis. [PDF]
Cheungpasitporn W+7 more
europepmc +1 more source
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato+9 more
wiley +1 more source