Results 151 to 160 of about 394,846 (264)

Altered Endothelin Receptor Expression in Idiopathic Male Infertility: A Potential Therapeutic Target. [PDF]

open access: yesUrol Res Pract
Weiten R   +6 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani   +5 more
wiley   +1 more source

Endothelin-1 signaling in the kidney: recent advances and remaining gaps. [PDF]

open access: yesAm J Physiol Renal Physiol
Brooks AJ   +2 more
europepmc   +1 more source

Advancing antihypertensive drug development

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu   +5 more
wiley   +1 more source

Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring

open access: yesJournal of Sleep Research, Volume 34, Issue 4, August 2025.
Effects of gestational intermittent hypoxia on maternal, fetal and offspring respiratory system. In black, effects in humans; in red, in vitro effects; in blue, effects in animal models. Summary Obstructive sleep apnea (OSA) is a common sleep disorder that is associated with a wide variety of health conditions, including cardiovascular, cerebrovascular,
Esther Valverde‐Pérez   +4 more
wiley   +1 more source

Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin‐1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis

open access: yesArthritis &Rheumatology, Volume 77, Issue 7, Page 901-913, July 2025.
Objective Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin‐1 type A receptor (ETAR), leading to autoantibody‐mediated ...
Wieke M. van Oostveen   +8 more
wiley   +1 more source

Research trends and performance of endothelin A receptor antagonist in kidney care: a bibliometric analysis. [PDF]

open access: yesRen Fail
Cheungpasitporn W   +7 more
europepmc   +1 more source

Serum Type I Interferon Score for Prediction of Clinically Meaningful Disease Progression in Limited Cutaneous Systemic Sclerosis

open access: yesArthritis &Rheumatology, Volume 77, Issue 7, Page 929-941, July 2025.
Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato   +9 more
wiley   +1 more source

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