Results 181 to 190 of about 42,145 (224)

Endothelin induces dopamine release from rat striatum via endothelin-B receptors

Neuroscience, 1998
The aim of the present study was to determine whether local administration of endothelin induces the release of dopamine in the rat striatum and to characterize and localize endothelin receptors in this brain region. Local injection of endothelin-1 (10 pmol) into the ventral striatum of urethane-anaesthetized rats caused an increase of 8 microM in the ...
K M, Webber, J N, Pennefather, G A, Head, M, van den Buuse   +3 more
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Subtype-Specific Endothelin-A and Endothelin-B Receptor Desensitization Correlates with Differential Receptor Phosphorylation

Journal of Cardiovascular Pharmacology, 1998
In the rat cardiovascular system endothelin-1 (ET-1) elicits prolonged physiologic responses mediated by the ETA receptor, whereas the effects mediated by the ETB receptor are transient. The molecular mechanisms for the subtype-specific responses are not yet clear. However, post-translational modifications such as phosphorylation and palmitoylation may
H, Cramer, W, Müller-Esterl, C, Schroeder   +2 more
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Thermostabilization of the Human Endothelin Type B Receptor

Journal of Molecular Biology, 2016
The peptide hormone endothelin, produced by the vascular endothelium, is involved in several physiological functions, including maintenance of vascular tone and humoral homeostasis. Endothelin transmits signals through the endothelin receptor, a G-protein-coupled receptor.
Akiko, Okuta, Kazutoshi, Tani, Shoko, Nishimura, Yoshinori, Fujiyoshi, Tomoko, Doi   +4 more
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Endothelin B receptor stimulation inhibits suicidal erythrocyte death

The FASEB Journal, 2010
ABSTRACT Endothelins (ETs), potent endothelium‐derived mediators, stimulate formation of nitric oxide, which, in turn, protects against suicidal erythrocyte death or eryptosis, characterized by phosphatidylserine exposure at the erythrocyte surface and triggered by increase in cytosolic Ca 2+
Foeller, Michael, Mahmud, Hasan, Qadri, Syed M., Gu, Shuchen, Braun, Manuel, Bobbala, Diwakar, Hocher, Berthold (Prof.), Lang, Florian   +7 more
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Downregulation of Endothelin B Receptors in Cardiomyopathic Hamsters

Cardiology, 1998
The mechanisms responsible for abnormal fluid retention in congestive heart failure (CHF) are unclear. Studies were conducted to elucidate how endothelin (ET) may contribute to salt and water retention. Cardiomyopathic (CM) hamsters with moderate heart failure were employed for in vivo and in vitro trials.
W H, Wong, B P, Wong, E F, Wong, M H, Huang, N L, Wong   +4 more
openaire   +2 more sources

Endothelin-B Receptor-Mediated Suppression of Endothelial Apoptosis

Journal of Cardiovascular Pharmacology, 1998
Endothelin (ET)-1 is an endothelium-derived vasoconstrictor as well as a mitogen. We have recently described a novel role of ET-1 as a survival factor for rat endothelial cells from serum deprivation-induced apoptosis. The present study was designed to determine which receptor subtype (ETA or ETB) is responsible for and what intracellular mediators are
M, Shichiri, F, Marumo, Y, Hirata
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Dissociation Characteristics of Endothelin Receptor Agonists and Antagonists in Cloned Human Type-B Endothelin Receptor

Endothelium, 1997
The human type-B endothelin receptor (h-ETB) was cloned from human lung poly A+RNA and stably expressed in CHO cells. Endothelin (ET) receptor binding and stimulation of PI hydrolysis demonstrated that the cloned h-ETB receptor is functional and linked to intracellular signal transduction pathways in CHO cells.
W J, Chiou, S R, Magnuson, D, Dixon, S, Sundy, T J, Opgenorth, J R, Wu-Wong   +5 more
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Altered endothelin-3 and endothelin-B receptor mRNA expression in hirschsprung's disease

Journal of Pediatric Surgery, 1999
Recently, the endothelin-3 (EDN3) and endothelin-B receptor (EDNRB) gene have been recognized as susceptibility genes for Hirschsprung's disease (HD). However, gene mutations have been observed only in limited cases, and the role of EDN3 in the pathogenesis and motility dysfunction in HD is not understood fully.
T, Oue, P, Puri
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Endothelin-1 Enhances Pressor Responses to Norepinephrine: Involvement of Endothelin-B Receptor

Journal of Cardiovascular Pharmacology, 1998
We investigated the effects of endothelin-1 (ET-1) on pressor responses to norepinephrine (NE) in perfused rat mesenteric arteries. Perfusion of the arteries with a subpressor dose of ET-1 (3 x 10(-10) M) for 15 min markedly enhanced the pressor responses to NE (10(-6) and 3 x 10(-6) M), and this effect was significantly prevented by BQ788 (10(-6) M ...
S, Kita, Y, Taguchi, Y, Matsumura
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Augmented expression of endothelin‐1, endothelin‐3 and the endothelin‐B receptor in breast carcinoma

Histopathology, 2000
AimsEndothelins (ETs) are peptides expressed in many tumours which may stimulate angiogenesis and desmoplasia. Because ETs have not been extensively studied mammary neoplasia, we assessed ET protein and mRNA expression and receptor mRNA expression in normal and neoplastic breast tissues.Methods and resultsTissues from five normal breasts, six ...
K, Alanen, D X, Deng, S, Chakrabarti
openaire   +2 more sources