Results 31 to 40 of about 394,846 (264)

Blockade of endothelin-1 receptor B regulates molecules of the major histocompatibility complex in sickle cell disease

Frontiers in Immunology, 2023
Major Histocompatibility Complex (MHC) molecules have been proposed to play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules following exposure to cytokines.
Yaritza Inostroza-Nieves, Yaritza Inostroza-Nieves, Yaritza Inostroza-Nieves, Alicia Rivera, Alicia Rivera, Alicia Rivera, José R. Romero   +6 more
doaj   +1 more source

Aberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis

Acta Dermato-Venereologica, 2019
Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong, Xia Wu, Wei Zhang, Jie Zhang, Xiaofan Chen, Shihong Chen, Haiyan Huang, Yong Yang, Bo Yu, Xia Dou   +9 more
doaj   +1 more source

Endothelins and liver cirrhosis

Portal Hypertension & Cirrhosis, 2022
Endothelins are a family of 21‐amino acid oligopeptides, called endothelin‐1 (ET‐1), endothelin‐2 (ET‐2), and endothelin 3 (ET‐3). Endothelins act on hepatocytes, liver endothelial cells, and Kupffer cells in a paracrine or autocrine manner through two G
Necati Örmeci
doaj   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Endothelin signalling mediates experience-dependent myelination in the CNS

eLife, 2019
Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endothelin receptor B
Matthew Swire, Yuri Kotelevtsev, David J Webb, David A Lyons, Charles ffrench-Constant   +4 more
doaj   +1 more source

Bioinformatics analysis identifies key genes of prognostic value in lung cancer [PDF]

Journal of Men's Health, 2023
Lung cancer is the most common human malignancy worldwide and can be divided into different types of carcinomas depending on their pathological features.
Dan Song, Li Sun
doaj   +1 more source

Generation and characterization of rendomab-B1, a monoclonal antibody displaying potent and specific antagonism of the human endothelin B receptor

mAbs, 2013
Endothelin B receptor (ETBR) is a G protein-coupled receptor able to bind equally to the three identified human endothelin peptides. It is expressed primarily on vascular endothelial cells and involved in various physiological processes including ...
B. Allard, A. Wijkhuisen, A. Borrull, Frédérique Deshayes, F. Priam, P. Lamourette, F. Ducancel, D. Boquet, J. Couraud   +8 more
semanticscholar   +1 more source

Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. [PDF]

PLoS ONE, 2018
To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes.Membranes were obtained from eyes undergoing ...
William Chang, Michelle Lajko, Amani A Fawzi   +2 more
doaj   +1 more source

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma

British Journal of Cancer, 2013
Background:The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC ...
Tetsuya Tanaka, Masayuki Sho, T. Takayama, K. Wakatsuki, S. Matsumoto, K. Migita, M. Ito, Kaoru Hamada, Yoshiyuki Nakajima   +8 more
semanticscholar   +1 more source

Downregulation of Endothelin B Receptors in Cardiomyopathic Hamsters

Cardiology, 1998
The mechanisms responsible for abnormal fluid retention in congestive heart failure (CHF) are unclear. Studies were conducted to elucidate how endothelin (ET) may contribute to salt and water retention. Cardiomyopathic (CM) hamsters with moderate heart failure were employed for in vivo and in vitro trials.
Wendy H.Y. Wong, Eric F.C. Wong, Norman L.M. Wong, Bonita P.H. Wong, Min-Huo Huang   +4 more
openaire   +3 more sources