Results 51 to 60 of about 394,846 (264)
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium‐Derived Endothelin‐1
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundAcute psychosocial stress provokes increases in circulating endothelin‐1 (ET‐1) levels in humans and animal models. However, key questions about the physiological function and cellular source of stress‐induced ET‐1 remain unanswered.
Brandon M. Fox +9 more
doaj +1 more source
Bioinformation, 2012 In cardiovascular system, activation of Endothelin receptors causes vasoconstriction which leads to Pulmonary Arterial Hypertension (PAH). Endothelin receptor antagonism has emerged as an important therapeutic strategy in pulmonary arterial hypertension.
D. J. Rayalu +5 more
semanticscholar +1 more source
Autocrine Role for the Endothelin-B Receptor in the Secretion of Adrenomedullin [PDF]
Hypertension, 1998 Abstract —Adrenomedullin, originally discovered in human pheochromocytoma, is a vasodilating and natriuretic peptide of vascular endothelial and smooth muscle cell origin. Although endothelin-1 (ET-1) has been implicated as a vasoconstricting and growth-promoting peptide of endothelial origin, it may more importantly function ...
Michihisa Jougasaki +3 more
openaire +3 more sources
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source
Endothelin receptors promote schistosomiasis-induced hepatic fibrosis via splenic B cells.
PLoS Pathogens, 2020 Endothelin receptors (ETRs) are activated by vasoactive peptide endothelins and involved in the pathogenesis of hepatic fibrosis. However, less is known about the role of ETRs in Schistosoma (S.) japonicum-induced hepatic fibrosis. Here, we show that the
Hongyan Kong +10 more
doaj +1 more source
Advanced Science, EarlyView.This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo +13 more
wiley +1 more source
Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries. [PDF]
PLoS ONE, 2013 BACKGROUND AND PURPOSE: Male-female differences may significantly impact stroke prevention and treatment in men and women, however underlying mechanisms for sexual dimorphism in stroke are not understood.
Hilda Ahnstedt +6 more
doaj +1 more source
An Antibody–Drug Conjugate Targeting the Endothelin B Receptor for the Treatment of Melanoma
Clinical Cancer Research, 2011 Purpose: To identify and evaluate targets amenable to antibody therapy in melanoma. Experimental Design: We searched for mRNA transcripts coding for cell-surface proteins with expression patterns similar to that of the melanoma oncogene MITF.
Jyoti Asundi +9 more
semanticscholar +1 more source