Results 61 to 70 of about 42,145 (224)

A review of sitaxsentan sodium in patients with pulmonary arterial hypertension

Vascular Health and Risk Management, 2007
Aaron B WaxmanDepartment of Internal Medicine, Pulmonary Critical Care Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USAAbstract: Pulmonary arterial hypertension (PAH) is a life threatening, progressive condition which ...
Aaron B Waxman
doaj  

Right Ventricular Hypertrophy in Spontaneously Hypertensive Rats (SHR/NHsd) Is Associated with Inter-Individual Variations of the Pulmonary Endothelin System

Biology
Spontaneously hypertensive rats (SHRs) develop severe hypertension and subsequently left ventricular hypertrophy. Whether they also develop right ventricular hypertrophy is not clear. We analyzed 76 female SHRs (strain SHR/NHsd) and observed severe right
Alicia Langer, Rolf Schreckenberg, Klaus-Dieter Schlüter   +2 more
doaj   +1 more source

Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells

Scientific Reports, 2018
Individuals with Trisomy 21 (T21) exhibit numerous hematological abnormalities, including reductions in numbers of circulating B and T lymphocytes. To elucidate molecular mechanisms underlying these phenotypes, we differentiated human isogenic disomic ...
Glenn A. MacLean, Jennifer McEldoon, Jialiang Huang, Jeremy Allred, Matthew C. Canver, Stuart. H. Orkin   +5 more
doaj   +1 more source

Endothelin receptors promote schistosomiasis-induced hepatic fibrosis via splenic B cells.

PLoS Pathogens, 2020
Endothelin receptors (ETRs) are activated by vasoactive peptide endothelins and involved in the pathogenesis of hepatic fibrosis. However, less is known about the role of ETRs in Schistosoma (S.) japonicum-induced hepatic fibrosis. Here, we show that the
Hongyan Kong, Jinan He, Shusen Guo, Qiqin Song, Dandan Xiang, Ran Tao, Haijing Yu, Guang Chen, Zhiyong Huang, Qin Ning, Jiaquan Huang   +10 more
doaj   +1 more source

A Novel Pathway Involving Progesterone Receptor, Endothelin-2, and Endothelin Receptor B Controls Ovulation in Mice [PDF]

Molecular Endocrinology, 2006
AbstractThe steroid hormone progesterone (P) plays a pivotal role during ovulation. Mice lacking P receptor (Pgr) gene fail to ovulate due to a defect in follicular rupture. The P receptor (PGR)-regulated pathways that modulate ovulation, however, remain poorly understood. To identify these pathways, we performed gene expression profiling using ovaries
Gopinath S, Palanisamy, Yong-Pil, Cheon, Jaeyeon, Kim, Athilakshmi, Kannan, Quanxi, Li, Marcey, Sato, Srinivasa R, Mantena, Regine L, Sitruk-Ware, Milan K, Bagchi, Indrani C, Bagchi   +9 more
openaire   +2 more sources

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

eLife
Peripheral sensory neurons regenerate their axons after injury to regain function, but this ability declines with age. The mechanisms behind this decline are not fully understood.
Rui Feng, Sarah F Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cedric G Geoffroy, Valeria Cavalli   +7 more
doaj   +1 more source

Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries. [PDF]

PLoS ONE, 2013
BACKGROUND AND PURPOSE: Male-female differences may significantly impact stroke prevention and treatment in men and women, however underlying mechanisms for sexual dimorphism in stroke are not understood.
Hilda Ahnstedt, Lei Cao, Diana N Krause, Karin Warfvinge, Hans Säveland, Ola G Nilsson, Lars Edvinsson   +6 more
doaj   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source