Results 81 to 90 of about 394,846 (264)

Endothelin-1 Inhibits Apoptosis in Prostate Cancer

Neoplasia: An International Journal for Oncology Research, 2005
Endothelin-1 (ET-1), produced by the prostate epithelia, likely plays an important role in the progression of prostate cancer. ET-1 can bind two receptor subtypes; generally, binding of the endothelin receptor A (ETA) induces a survival pathway, whereas ...
Joel B. Nelson, Michael S. Udan, Georgi Guruli, Beth R. Pflug   +3 more
doaj   +1 more source

Role for inflammatory markers in predicting right ventricular failure in mechanical assist device recipients

ESC Heart Failure, EarlyView.
Abstract Right ventricular failure (RVF) is a common complication following left ventricular assist device (LVAD) implantation and increases patient morbidity and mortality. Due to the complex and limited understanding of RVF pathophysiology, efforts to prognosticate RVF after LVAD have been challenging.
Abdul‐Fatawu Osman, Shane S. Scott, Ebubechukwu O. Ezeh, Evans Osuji, Israel O. Ailemen, Mohamed H. Derbala, Salil Kumar, Asvin M. Ganapathi, Daniel B. Sims, Ashrith Guha, Bryan A. Whitson, Sakima A. Smith   +11 more
wiley   +1 more source

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

Neurobiology of Disease, 2014
The endothelin system is implicated in various human and animal glaucomas. Targeting the endothelin system has great promise as a treatment for human glaucoma, but the cell types involved and the exact mechanisms of action are not clearly elucidated ...
Gareth R. Howell, Katharine H. MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W.M. John   +6 more
doaj  

Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells

BMC Cell Biology, 2009
Background Endothelin-1 (ET-1) is a potent vasoactive peptide, which induces vasoconstriction and proliferation in vascular smooth muscle cells (VSMCs) through activation of endothelin type A (ETA) and type B (ETB) receptors.
Edvinsson Lars, Chen Qing-wen, Xu Cang-Bao   +2 more
doaj   +1 more source

Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha.

Blood, 2008
Pulmonary hypertension (PHT) develops in sickle cell disease (SCD) and is associated with high mortality. We previously showed that erythroid cells produce placenta growth factor (PlGF), which activates monocytes to induce proinflammatory cytochemokines,
Nitin Patel, Caryn S. Gonsalves, P. Malik, V. Kalra   +3 more
semanticscholar   +1 more source

The role of endothelin receptors (ETRA/B) in fibrocyte differentiation

Life Sciences, 2013
Introduction Scleroderma (SSc) is an autoimmune connective tissue disease of unknown aetiology. Pulmonary involvement including the development of pulmonary arterial hypertension (PAH) is characterised by vascular remodelling, collagen deposition and expression of connective tissue growth factor (CTGF).
S Trinder, Bahja Ahmed Abdi, Christopher P. Denton, Alan M. Holmes, David C. Budd, David Abraham, Xu Shiwen   +6 more
openaire   +2 more sources

Mono and combination therapies in pulmonary arterial hypertension patients with comorbidities: A COMPERA analysis

ESC Heart Failure, EarlyView.
AIM This analysis provides a comparison of the efficacy of initial mono and combination therapy in patients with PAH and cardiovascular comorbidities or with risk factors of HFpEF (heart failure with preserved ejection fractioin).METHOD Data from the European COMPERA registry were used for a matched pair analysis.
Dirk Skowasch, Christine Pausch, Doerte Huscher, David Pittrow, Judith Wede, Fabian Kreimendahl, Stephan Rosenkranz, Stephan Beckmann, Matthias Held, Ekkehard Grünig, H. Ardeschir Ghofrani, Hans Klose, Andris Skride, Michael Halank, Stefan Stadler, Marion Delcroix, Anton Vonk‐Noordegraaf, Ralf Ewert, Grzegorz Kopec, Marius M. Hoeper, Karen M. Olsson   +20 more
wiley   +1 more source

Attenuation of experimental hepatopulmonary syndrome in endothelin B receptor-deficient rats.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2009
Experimental hepatopulmonary syndrome (HPS) after common bile duct ligation (CBDL) in rat is accompanied by increased lung vascular endothelial endothelin B (ETB) receptor expression and increased circulating levels of endothelin-1 (ET-1).
Junlan Zhang, Y. Ling, Liping Tang, Bao Luo, D. Pollock, M. Fallon   +5 more
semanticscholar   +1 more source

The effects of early exercise on cardiovascular biomarkers in patients with congestive heart failure

ESC Heart Failure, EarlyView.
Abstract Background Exercise training improves functional outcomes in chronic heart failure (HF), but the effects of early in‐hospital physical activity on cardiovascular biomarkers and prognosis in acute congestive heart failure (AHF) patients remain unclear.
Yanxiang Sun, Xuansheng Huang, Bing Hu, Zidi Wu, Yanchun Zhang, Yong Yuan, Li Feng   +6 more
wiley   +1 more source

Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension

Cellular Physiology and Biochemistry, 2017
Background/Aims: Studies have shown that a change in endothelin receptor expression in the artery is related to pregnancy-induced hypertension (PIH). However, the mechanism underlying this change remains unclear. Methods: To test whether the distribution
Yuan Sun, Xicheng Zhang, Zhaolei Chen, Miao Xu, Minghui Ou   +4 more
doaj   +1 more source