Results 171 to 180 of about 71,317 (233)

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Serum Insulin-like Growth Factor-II Is Associated with Poor Poststroke Outcomes in Males: A Secondary Analysis. [PDF]

Int J Mol Sci
Glamheden C, Åberg ND, Gadd G, Åberg D.   +3 more
europepmc   +1 more source

Hormonal adaptations to weight loss: Responses to an oral glucose load 4 weeks after obesity surgery and low‐energy diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims In addition to weight loss, obesity surgery (OS) leads to metabolic improvements that seem at least partly independent of weight loss and are also mediated by various endocrine pathways and the brain. For the first time, we compared the short‐term effects of weight loss achieved by either OS or a low‐energy diet (LED) on several hormonal ...
Giovanni Fanni, Fleur Hukema, Susanne Hetty, Argyri Mathioudaki, Magnus Sundbom, Ulf Risérus, Joel Kullberg, Maria J. Pereira, Håkan Ahlström, Jan W. Eriksson   +9 more
wiley   +1 more source

Backtracking to the Brain: A Journey From Cirrhosis to Hypothalamic Insight. [PDF]

Cureus
Haley HN, Ikram FG, Ward AM.
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

The IGF System and Aging.

Endocr Rev
Conover CA, Oxvig C.
europepmc   +1 more source

Developing cancer vaccine with carcinoembryonic antigen and IGF-1R as immunostimulants using immunoinformatics approach. [PDF]

Korean J Clin Oncol
Ezediuno LO, Ockiya MA, Awoniyi LO, Sangodare AO, David KB, Robert FO.   +5 more
europepmc   +1 more source

Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS). Materials and Methods This follow‐up study evaluated changes in the oral microbiome in a sub‐cohort of 42 patients with MetS during prolonged fasting. Periodontal parameters such as bleeding on probing (BOP), plaque index (PI) and
C. L. Pappe, S. Kleine Bardenhorst, K. Prior, N. Steckhan, A. Michalsen, B. Ehmke, H. Dommisch, D. Hagenfeld   +7 more
wiley   +1 more source

Signaling Pathways Driving MSC Osteogenesis: Mechanisms, Regulation, and Translational Applications. [PDF]

Int J Mol Sci
Wang L, Ruan M, Bu Q, Zhao C.
europepmc   +1 more source

PIK3R1 mutations in individuals with insulin resistance or growth retardation: Case series and in silico functional analysis

Journal of Diabetes Investigation, EarlyView.
We present a report on SHORT syndrome caused by PIK3R1 mutations, including findings from in silico analysis. Our results demonstrate that these mutations impair the ability of p85α to interact with phosphopeptides. ABSTRACT Aims/Introduction Phosphatidylinositol 3‐kinase (PI3K) plays a key role in insulin signaling, and mutations in PIK3R1, which ...
Tomofumi Takayoshi, Yushi Hirota, Aki Sugano, Kenji Sugawara, Takehito Takeuchi, Mika Ohta, Kai Yoshimura, Seiji Nishikage, Akane Yamamoto, Yu Mimura, Shinji Higuchi, Jun Mori, Rie Kawakita, Tohru Yorifuji, Yutaka Takaoka, Wataru Ogawa   +15 more
wiley   +1 more source