The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. [PDF]
PLoS ONE, 2013 Methamphetamine (METH) is a highly addictive psychostimulant with no therapeutics registered to assist addicts in discontinuing use. Glutamatergic dysfunction has been implicated in the development and maintenance of addiction.
Rose Chesworth +3 more
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Anti-metabotropic glutamate receptor 5 coexistent anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review [PDF]
Frontiers in ImmunologyMetabotropic glutamate receptor 5 (mGluR5) antibody encephalitis is an infrequent clinical disorder, initially reported in 2011 among two patients presenting with limbic encephalitis and Hodgkin’s lymphoma.
Yixin Gu +9 more
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Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]
Protein SciAbstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Kondo Y +15 more
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Frontiers in Neurology, 2014 Antiglutamatergic drugs can relieve Parkinson’s disease (PD) symptoms and decrease L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias (LID).
Nicolas eMorin +3 more
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Differential Epigenetic Regulation of Glutamatergic Synapse Pathway in Adults With Prenatal Exposure to Famine. [PDF]
Eur J NeurosciUsing DNA methylation data collected on adults prenatally exposed to the Chinese famine of 1959–1961, this study reports the altered epigenetic regulation in genes of the glutamate synapse pathway in association with early‐life adversity. Our analysis revealed an overall pattern of reduced DNA methylation of the pathway genes that is more pronounced in
Tan Z, Li W, Wang W, Zhang D, Tan Q.
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Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
Journal of Biomedical Science, 2009 The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by glutamate receptor agonists including ...
Ko Chien-Hsin +4 more
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Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery. [PDF]
J Cell Commun SignalThe top row shows key drivers‐KRAS, c‐Myc and HIF‐1a‐alongside gut and tumor microbiota, all converging on glutamine metabolism in PDAC. At the center, glutamine handling is depicted as the linchpin of tumor growth, biosynthesis and immune modulation. The green panel lists major intervention strategies: DON‐loaded nanoparticles, prodrugs (DRP‐104/JHU ...
Su M, Qin H, Shen J, An H, Cao Y.
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Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia [PDF]
Basic Clin Pharmacol ToxicolABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Magnussen J.
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GABA<sub>B</sub> Receptors Mediate Intracellular Calcium Release in Astrocytes of the Prefrontal Cortex. [PDF]
Eur J NeurosciWe took advantage of GLAST‐promoter driven GCaMP6s expression in astrocytes to study Ca2+ signaling in astrocytes of the young adult prefrontal cortex in response to GABA with confocal Ca2+ imaging. The results show that GABA induces Ca2+ signaling via the stimulation of the metabotropic GABAB receptor in astrocytes.
Bostel J, Kürten AJ, Beiersdorfer A.
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Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). [PDF]
PLoS ONE, 2010 Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 (mGluR5) is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout (KO),
Christopher M Olsen +3 more
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