Results 101 to 110 of about 476,675 (312)

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]

, 2014
BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna, Desplats, Paula, Masliah, Eliezer, Overk, Cassia R, Patrick, Christina, Price, Diana L, Rockenstein, Edward, Shaked, Gideon, Spencer, Brian, Ubhi, Kiren   +9 more
core   +3 more sources

Metabotropic glutamate receptor 5 knockout rescues obesity phenotype in a mouse model of Huntington’s disease

Scientific Reports, 2022
Obesity represents a global health problem and is characterized by metabolic dysfunctions and a low-grade chronic inflammatory state, which can increase the risk of comorbidities, such as atherosclerosis, diabetes and insulin resistance.
Rebeca P. M. Santos, Roberta Ribeiro, Talita H. Ferreira-Vieira, Rosaria D. Aires, Jessica M. de Souza, Bruna S. Oliveira, Anna Luiza D. Lima, Antônio Carlos P. de Oliveira, Helton J. Reis, Aline S. de Miranda, Erica M. L. Vieira, Fabiola M. Ribeiro, Luciene B. Vieira   +12 more
doaj   +1 more source

Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics

Biomedical and Biotechnology Research Journal, 2021
Glutamine, an excitatory neurotransmitter, is necessary for physiological as well as pathological processes. Other than neuronal disorders and/or cancers, glutamate receptors have also been associated with an array of other malignancies. The metabotropic
Shree Goyal, Pallab Chakraborty, Balasubramaniam Shankar   +2 more
doaj   +1 more source

Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]

, 2010
A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv   +1 more source

Temporal Profiling of Male Cortical Astrocyte Transcription Predicts Molecular Shifts From Early Development to Aging

Glia, EarlyView.
Comprehensive analysis of cortical astrocyte gene expression across the lifespan. Profiling dynamic changes of key astrocyte genes reveals functional shifts. Astrocytes contribute to gene‐length‐dependent transcription decline in the aging brain. ABSTRACT Astrocytes are the most abundant glial cell type in the central nervous system (CNS).
Xiaoran Wei, Jiangtao Li, Michelle L. Olsen   +2 more
wiley   +1 more source

A biophysical network model reveals the link between deficient inhibitory cognitive control and major neurotransmitter and neural connectivity hypotheses in schizophrenia [PDF]

arXiv, 2021
We address a biophysical network dynamical model to study how the modulation of dopamine (DA) activity and related N-methyl-d-aspartate (NMDA) glutamate receptor activity as well as the emerging Pre-Frontal Cortex (PFC) functional connectivity network (FCN) affect inhibitory cognitive function in schizophrenia in an antisaccade task.
arxiv  

Cargo binding promotes KDEL receptor clustering at the mammalian cell surface [PDF]

Sci. Rep. 6, 28940, 2016, 2017
Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from chemotactic receptors in bacteria to ...
arxiv   +1 more source

Multi‐Omic Analysis Reveals Astrocytic Annexin‐A2 as Critical for Network‐Level Circadian Timekeeping in the Suprachiasmatic Nucleus

Glia, EarlyView.
ABSTRACT The mammalian suprachiasmatic nucleus (SCN) orchestrates daily (circadian) rhythms of physiology and behavior by broadcasting timing cues generated autonomously by its mutually reinforcing network of ~10,000 neurons and ~3000 astrocytes. Although astrocytic control of extracellular glutamate and GABA has been implicated in driving circadian ...
Andrew P. Patton, Toke P. Krogager, Elizabeth S. Maywood, Nicola J. Smyllie, Emma L. Morris, Mark Skehel, Michael H. Hastings   +6 more
wiley   +1 more source

Formation and Stability of Synaptic Receptor Domains [PDF]

Phys. Rev. Lett. 106, 238104 (2011), 2010
Neurotransmitter receptor molecules, concentrated in postsynaptic domains along with scaffold and a number of other molecules, are key regulators of signal transmission across synapses. Employing experiment and theory, we develop a quantitative description of synaptic receptor domains in terms of a reaction-diffusion model.
arxiv   +1 more source

Activated Nuclear Metabotropic Glutamate Receptor mGlu5 Couples to Nuclear Gq/11 Proteins to Generate Inositol 1,4,5-Trisphosphate-mediated Nuclear Ca2+ Release*

Journal of Biological Chemistry, 2008
Recently we have shown that the metabotropic glutamate 5 (mGlu5) receptor can be expressed on nuclear membranes of heterologous cells or endogenously on striatal neurons where it can mediate nuclear Ca2+ changes.
Vikas Kumar, Y. Jong, K. O’Malley
semanticscholar   +1 more source