Results 101 to 110 of about 49,550 (244)
Structural Insights into Metabotropic Glutamate Receptor Activation
Nature, 2018 Metabotropic glutamate receptors are family C G-protein-coupled receptors. They form obligate dimers and possess extracellular ligand-binding Venus flytrap domains, which are linked by cysteine-rich domains to their 7-transmembrane domains. Spectroscopic
A. Koehl +16 more
semanticscholar +1 more source
Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Cell Reports, 2023 Summary: Obesity-mediated hypoxic stress underlies inflammation, including interferon (IFN)-γ production by natural killer (NK) cells in white adipose tissue. However, the effects of obesity on NK cell IFN-γ production remain obscure.
Hee-Hoon Kim +19 more
doaj
Journal of Pharmacological Sciences, 2015 Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia.
Hirohiko Hikichi +10 more
doaj +1 more source
Paraneoplastic cerebellar ataxia and antibodies to metabotropic glutamate receptor 2
Neurology: Neuroimmunology & Neuroinflammation, 2019 Objective To report the presence of a new neuronal surface antibody against the metabotropic glutamate receptor 2 antibody (mGluR2-Ab) in 2 patients with paraneoplastic cerebellar ataxia.
R. Ruiz-García +11 more
semanticscholar +1 more source
The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study
Brain and Behavior, Volume 15, Issue 7, July 2025.This study is the first to employed TSMR to investigate the causal relationship between 20 acylcarnitines and neurocognitive outcomes. The findings indicate that lower genetically predicted levels of acetyl‐L‐carnitine and butyrylcarnitine are associated with diminished cognitive performance, underscoring their potential clinical implications in the ...
Sisi Luan +4 more
wiley +1 more source
Frontiers in Pharmacology, 2012 Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux +7 more
doaj +1 more source
ACS Chemical Neuroscience, 2018 Metabotropic glutamate receptor 5 (mGlu5) plays a key role in synaptic information storage and memory, which is a well-known target for a variety of psychiatric and neurodegenerative disorders. In recent years, the increasing efforts have been focused on
Tingting Fu +8 more
semanticscholar +1 more source
European Journal of Pain, Volume 29, Issue 6, July 2025.ABSTRACT Background Glutamate, the primary neurotransmitter released by nociceptors, is predominantly synthesised by the enzyme Glutaminase 1 (GLS1). The involvement of GLS1 in pain pathways is well supported, as Gls1 heterozygous mice exhibit altered nociception and GLS1 levels increase in the dorsal root ganglia (DRG) under chronic peripheral ...
Anabel Martínez‐Padilla +4 more
wiley +1 more source
Metabotropic glutamate receptor 5 binding in male patients with alcohol use disorder
Translational Psychiatry, 2018 Glutamate signaling plays a major role in addiction. Preclinical research strongly suggests an implication of G-protein-coupled metabotropic glutamate receptor subtype 5 (mGluR5) in nicotine addiction and alcohol use disorder.
F. Akkus +8 more
semanticscholar +1 more source