Results 131 to 140 of about 49,550 (244)

Allosterism in the adenosine A2A and cannabinoid CB2 heteromer

British Journal of Pharmacology, Volume 182, Issue 14, Page 3371-3384, July 2025.
Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent, Iu Raïch, Angel Gonzalez, Jaume Lillo, Nil Casajuana‐Martin, Rafael Franco, Leonardo Pardo, Gemma Navarro   +7 more
wiley   +1 more source

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

Metabotropic Glutamate 5 Receptor (mGluR5) Antagonists Decrease Nicotine Seeking, But Do Not Affect the Reinforcement Enhancing Effects of Nicotine

Neuropsychopharmacology, 2008
M. Palmatier, Xiu Liu, E. Donny, A. Caggiula, A. Sved   +4 more
semanticscholar   +1 more source

Dissecting the Signaling Pathways Involved in the Crosstalk between Metabotropic Glutamate 5 and Cannabinoid Type 1 Receptors

Molecular Pharmacology, 2016
I. G. Olmo, T. H. Ferreira-Vieira, F. Ribeiro   +2 more
semanticscholar   +1 more source

Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism

Journal of Neuroscience, 2002
N. Breysse, C. Baunez, W. Spooren, F. Gasparini, M. Amalric   +4 more
semanticscholar   +1 more source

Metabotropic Glutamate 5 Receptor Blockade Alleviates Akinesia by Normalizing Activity of Selective Basal-Ganglia Structures in Parkinsonian Rats

Journal of Neuroscience, 2003
N. Breysse, M. Amalric, P. Salin
semanticscholar   +1 more source

Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review. [PDF]

CNS Neurosci Ther
Huang M, Luo L, Wang W, Xu H, Chen M, Ma X, Xu T.   +6 more
europepmc   +1 more source

Spontaneous partial resolution of autoimmune-mediated brain MRI abnormalities before immunotherapy in anti-metabotropic glutamate receptor 5 encephalitis: a case report. [PDF]

Front Immunol
Chen J, Tang X, Wang L, Guo D, Cao L, Lu K.   +5 more
europepmc   +1 more source

18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry

Journal of Nuclear Medicine, 2013
D. Wong, R. Waterhouse, H. Kuwabara, Jongho Kim, James Robert Brašić, W. Chamroonrat, Michael Stabins, D. Holt, R. Dannals, T. Hamill, P. Mozley   +10 more
semanticscholar   +1 more source

Activation of Endoplasmic Reticulum-Localized Metabotropic Glutamate Receptor 5 (mGlu₅) Triggers Calcium Release Distinct from Cell Surface Counterparts in Striatal Neurons. [PDF]

Biomolecules
Jong YI, Harmon SK, O'Malley KL.
europepmc   +1 more source