Results 51 to 60 of about 49,550 (244)

Advancements in DNA‐Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions

Advanced Science, EarlyView.
DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan, Ming Cai, Yiyu Wang, Hong‐Hui Wang, Zhou Nie   +4 more
wiley   +1 more source

Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF [PDF]

Neurology, 2013
A 35-year-old man developed progressive memory problems and personality changes over the course of 6 months. This amnesia culminated in overt functional impairment as he began getting lost in familiar places and paid his rent multiple times in one day. He then displayed increased aggression and was admitted to hospital after assaulting a family member.
Giuseppe Gullo, Hugh Adler, Aine Merwick, Josep Dalmau, Arimin Mat, Niall Tubridy, Geoff Chadwick   +6 more
openaire   +3 more sources

Structural Basis of GABAB Receptor Activation during Evolution

Advanced Science, EarlyView.
This study explores the structural and functional mechanisms of the drosophila GABAB receptor, a key role in neurotransmission. Using cryo‐EM, the research reveals how the receptor's activation differs from its human counterpart, highlighting unique evolutionary features.
Guofei Hou, Shenglan Zhang, Cangsong Shen, Suyu Ji, Binqian Zou, Chanjuan Xu, Liang Li, Dandan Shen, Jiayin Liang, Haidi Chen, Philippe Rondard, Cheng Deng, Jun He, Yan Zhang, Jianfeng Liu   +14 more
wiley   +1 more source

Norbin Is an Endogenous Regulator of Metabotropic Glutamate Receptor 5 Signaling [PDF]

Science, 2009
Norbin Knockout Metabotropic glutamate receptors (mGluRs) are critical neurotransmitter sensors implicated in central neuronal functions like learning and memory and in diseases of the nervous system. Wang et al. (p.
Marc Flajolet, Yi Nong, Anita Aperia, Shari G. Birnbaum, Jacob Bendor, Hong Wang, Hjalmar Brismar, Hjalmar Brismar, Linda Westin, Paul Greengard, Eric J. Nestler   +10 more
openaire   +3 more sources

Interactions between Metabotropic Glutamate 5 and Adenosine A2A Receptors in Normal and Parkinsonian Mice

Journal of Neuroscience, 2005
Evidence for heteromeric receptor complexes comprising adenosine A2A and metabotropic glutamate 5 (mGlu5) receptors in striatum has raised the possibility of synergistic interactions between striatal A2A and mGlu5 receptors.
A. Kachroo, L. Orlando, D. Grandy, Jiang-fan Chen, A. Young, M. Schwarzschild   +5 more
semanticscholar   +1 more source

Genome‐Wide Insights and Polygenic Risk Scores in Common Epilepsies: A Narrative Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT The research of single gene‐related disorders or pathogenic copy‐number variations (CNVs) has given a significant impetus to the shift from a diagnostic work‐up focused on epileptic syndromes to genomic approaches in individuals with severe pediatric‐onset epilepsies and in developmental and epileptic encephalopathies.
Mario Mastrangelo, Simona Petrucci, Giuliana Lentini, Marco Fabiani, Maria Piane, Francesco Pisani   +5 more
wiley   +1 more source

Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes [PDF]

Kidney International, 2012
In non-neuronal cells, glutamate is an extracellular signaling mediator. Since podocytes have glutamate-containing vesicles, we sought to determine glutamate receptor presence and action in glomerular cells. The metabotropic glutamate receptors (mGluR) 1, 5, 6, and 8 were found to be expressed in mouse brain and glomeruli; predominantly in podocytes ...
Xinyue Liang, Shan Mou, Xinyu Chen, Lihua Wang, Jiayuan Gao, Jiaqi Qian, Zhaohui Ni, Leyi Gu, Yucheng Yan, Qin Wang, Huili Dai, Liming Wang   +11 more
openaire   +2 more sources

NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation

Neural Plasticity, 2014
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses.
Tursonjan Tokay, Timo Kirschstein, Marco Rohde, Volker Zschorlich, Rüdiger Köhling   +4 more
doaj   +1 more source

Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats

BMC Neuroscience, 2008
Background Many studies have focused on the implication of the serotonin and dopamine systems in neuroadaptive responses to the recreational drug 3,4-methylenedioxy-metamphetamine (MDMA).
Malki Rana, Blomqvist Anna, Kindlundh-Högberg Anna MS, Schiöth Helgi B   +3 more
doaj   +1 more source

Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors.

Cerebral Cortex, 2006
Metabotropic glutamate 5 (mGlu5) receptors have been recently implicated in prefrontal cortex (PFC)-dependent executive functions because inhibition of mGlu5 receptors impairs working memory and worsens cognitive-impairing effects of NMDA receptor ...
H. Homayoun, B. Moghaddam
semanticscholar   +1 more source