Results 51 to 60 of about 54,795 (218)

The role of metabotropic glutamate receptor 5 in the pathogenesis of mood disorders and addiction:Combining preclinical evidence with human Positron Emission Tomography (PET) studies

Frontiers in Neuroscience, 2015
In the present review, we deliver an overview of the involvement of metabotropic glutamate receptor 5 (mGluR5) activity and density in pathological anxiety, mood disorders and addiction.
Sylvia eTerbeck, Funda eAkkus, Laurence Paul Chesterman, Gregor eHasler   +3 more
doaj   +1 more source

Autoimmune encephalitis with mGluR5 antibodies: A case series from China and review of the literature

Frontiers in Immunology, 2023
BackgroundOnly 15 patients of autoimmune encephalitis with metabotropic glutamate receptor 5 (mGluR5) antibodies have been reported worldwide since 2011, mostly from western countries.
Kundian Guo, Kundian Guo, Xu Liu, Xu Liu, Xue Gong, Xue Gong, Aiqing Li, Aiqing Li, Yue Liu, Yue Liu, Xingjie Li, Xingjie Li, Dong Zhou, Dong Zhou, Zhen Hong, Zhen Hong, Zhen Hong   +16 more
doaj   +1 more source

Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density

Translational Psychiatry, 2023
Animal models indicate that the endocannabinoid system (ECS) plays a modulatory role in stress and reward processing, both crucially impaired in addictive disorders.
Sara L. Kroll, Lea M. Hulka, Ann-Kathrin Kexel, Matthias Vonmoos, Katrin H. Preller, Valerie Treyer, Simon M. Ametamey, Markus R. Baumgartner, Carola Boost, Franziska Pahlisch, Cathrin Rohleder, F. Markus Leweke, Boris B. Quednow   +12 more
doaj   +1 more source

Pharmacological And Genetic Reversal Of Age-Dependent Cognitive Deficits Attributable To Decreased Presenilin Function [PDF]

, 2010
Alzheimer\u27s disease (AD) is the leading cause of cognitive loss and neurodegeneration in the developed world. Although its genetic and environmental causes are not generally known, familial forms of the disease (FAD) are attributable to mutations in a
Bell, A. J., Chiorean, S., Choi, C. H., Choi, R. J., Ferreiro, D., Ferrick, N. J., Fortini, M. E., Hinchey, P., Jongens, T. A., Koenigsberg, E., Kollaros, M., Liebelt, D. A., McBride, S. M.J., McDonald, T. V., Nguyen, H. T., Rudominer, R. L., Schoenfeld, B. P., Siwicki, Kathleen King, Sumida, A., Terlizzi, A. M.   +19 more
core   +2 more sources

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]

, 1995
To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +1 more source