Results 51 to 60 of about 476,675 (312)
Mechanisms associated with activation of intracellular metabotropic glutamate receptor, mGluR5 [PDF]
, 2016 The group 1 metabotropic glutamate receptor, mGluR5, is found on the cell surface as well as on intracellular membranes where it can mediate both overlapping and unique signaling effects.
Jong, Yuh-Jiin I, O\u27Malley, Karen L
core +2 more sources
European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022 Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna +3 more
wiley +1 more source
mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]
, 2018 In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba +16 more
core +2 more sources
Frontiers in Immunology, 2018 A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma.
Carlos Guevara +10 more
doaj +1 more source
High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv +1 more source
Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review [PDF]
, 2016 Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction.
Grayson, Danis R +4 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2021 The cellular mechanisms regulating dopamine (DA) release in the striatum have attracted much interest in recent years. By in vitro amperometric recordings in mouse striatal slices, we show that a brief (5 min) exposure to the metabotropic glutamate ...
Nicola B. Mercuri +10 more
doaj +1 more source
Modeling T1 Resting-State MRI Variants Using Convolutional Neural Networks in Diagnosis of OCD [PDF]
arXiv, 2023 Obsessive-compulsive disorder (OCD) presents itself as a highly debilitating disorder. The disorder has common associations with the prefrontal cortex and the glutamate receptor known as Metabotropic Glutamate Receptor 5 (mGluR5). This receptor has been observed to demonstrate higher levels of signaling from positron emission tomography scans measured ...
arxiv
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Lower Limbic Metabotropic Glutamate Receptor 5 Availability in Alcohol Dependence [PDF]
Journal of Nuclear Medicine, 2018 Animal studies suggest an important role for the metabotropic glutamate receptor subtype 5 (mGlu5) in the pathophysiology of alcohol dependence, but direct human evidence is lacking. The goal of this study was to investigate cerebral mGlu5 availability in alcohol-dependent subjects versus controls using 18F-3-fluoro-5-[(pyridin-3-yl)ethynyl ...
G. Leurquin-Sterk +9 more
semanticscholar +7 more sources