Results 131 to 140 of about 58,465 (248)

Preferential Localization of Muscarinic M1 Receptor on Dendritic Shaft and Spine of Cortical Pyramidal Cells and Its Anatomical Evidence for Volume Transmission

Journal of Neuroscience, 2010
Acetylcholine (ACh) plays important roles for higher brain functions, including arousal, attention, and cognition. These effects are mediated largely by muscarinic acetylcholine receptors (mAChRs). However, it remains inconclusive whether the mode of ACh-
Miwako Yamasaki, M. Matsui, Masahiko Watanabe   +2 more
semanticscholar   +1 more source

Xanomeline/trospium-induced polyuria: A patient case report [PDF]

Mental Health Clinician
Xanomeline/trospium is a newly approved agent for the management of schizophrenia. Unlike traditional antipsychotics, which are D2 receptor antagonists, xanomeline is an M1/M4 muscarinic acetylcholine receptor agonist coformulated with trospium, a ...
Henry Leach, PharmD, BCPP, Francesca DiGuglielmo, PharmD   +1 more
doaj   +1 more source

D₂ Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways [PDF]

, 2005
Regulator of G-protein signaling 9-2 (RGS9-2), a member of the RGS family of Gα GTPase accelerating proteins, is expressed specifically in the striatum, which participates in antipsychotic-induced tardive dyskinesia and in levodopa-induced dyskinesia. We
Axelrod, Jeffrey D., Barghshoon, Sami, Chen, Ching-Kang, Cheyette, Benjamin N. R., Ebert, Jana, Kovoor, Abraham, Lester, Henry A., Schwarz, Johannes, Schwarz, Sigrid, Seyffarth, Petra, Simon, Melvin I.   +10 more
core  

Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

Neurobiology of Disease, 2015
Clinical studies demonstrate that scopolamine, a non-selective muscarinic acetylcholine receptor (mAchR) antagonist, produces rapid therapeutic effects in depressed patients, and preclinical studies report that the actions of scopolamine require ...
Andrea Navarria, Eric S. Wohleb, Bhavya Voleti, Kristie T. Ota, Sophie Dutheil, Ashley E. Lepack, Jason M. Dwyer, Manabu Fuchikami, Astrid Becker, Filippo Drago, Ronald S. Duman   +10 more
doaj   +1 more source

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Nature Chemical Biology, 2020
S. Bradley, Colin Molloy, P. Valuskova, L. Dwomoh, Miriam Scarpa, M. Rossi, Lisa Finlayson, K. Svensson, E. Chernet, V. Barth, Karolina Gherbi, D. Sykes, Caroline A. Wilson, R. Mistry, P. Sexton, A. Christopoulos, A. Mogg, E. Rosethorne, S. Sakata, R. A. John Challiss, L. Broad, A. Tobin   +21 more
semanticscholar   +1 more source

Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.

PLoS ONE, 2019
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter, Laura Klein, Christin Helmschrodt, Angelika Richter   +3 more
doaj   +1 more source

UEG Week 2025 Poster Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley   +1 more source

Low Molecular Weight mRNA Encodes a Protein That Controls Serotonin 5-HT_(1c) and Acetylcholine M_1 Receptor Sensitivity in Xenopus Oocytes [PDF]

, 1991
Serotonin 5-HT_(1c) and acetylcholine M_1 receptors activate phosphoinositidase, resulting in an increased formation of IP_3 and 1,2 diacylglycerol.
Davidson, N., Hoger, J. H., Labarca, C., Lester, H. A., Walter, A. E., Yu, L.   +5 more
core  

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Effects of muscarinic M1 and M4 acetylcholine receptor stimulation on extinction and reinstatement of cocaine seeking in male mice, independent of extinction learning

Psychopharmacology, 2018
Kevin Stoll, R. Hart, C. Lindsley, M. Thomsen   +3 more
semanticscholar   +1 more source