Results 211 to 220 of about 58,465 (248)

Muscarinic M1-Receptor Agonists

CNS Drugs, 1995
Extensive degeneration of cholinergic neurons occurs early in Alzheimer’s disease and correlates with the loss of cognitive function. Cholinergic replacement therapies attempt to compensate for neuronal loss by increasing endogenously released acetylcholine or directly stimulating cholinergic receptors.
Neal R. Cutler, John J. Sramek
openaire   +2 more sources

Agonist induced phosphorylation of M1 muscarinic receptors

Life Sciences, 1995
73039
WAUGH, MG, NAHORSKI, S, TOBIN, AB
openaire   +3 more sources

Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline.

ACS Chemical Neuroscience, 2018
Preclinical and clinical data suggest that muscarinic acetylcholine receptor activation may be therapeutically beneficial for the treatment of schizophrenia and Alzheimer's diseases.
C. Thorn, Joshua Moon, Clinton A Bourbonais, J. Harms, J. Edgerton, Eda Stark, Stefanus J. Steyn, Christopher R Butter, J. Lazzaro, Rebecca E O'connor, M. Popiolek   +10 more
semanticscholar   +1 more source

Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.

European Journal of Pharmacology, 2004
The muscarinic toxin MT7 is the most selective ligand for the muscarinic M(1) receptors. Previous studies have shown that the toxin interacts with the antagonist-receptor complex and slows the antagonist dissociation rate, possibly by binding to an allosteric site and impeding the access to and egress from the orthosteric binding pocket. In the present
OLIANAS, MARIA CONCETTA, ADEM A, KARLSSON E, ONALI, PIER LUIGI   +3 more
openaire   +3 more sources

Use of m1-toxin as a selective antagonist of m1 muscarinic receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1993
m1-Toxin is the only ligand which is known to bind specifically to the extracellular face of genetically defined m1 muscarinic receptors; it binds pseudoirreversibly. A variety of studies were performed to evaluate the usefulness of m1-toxin as a selective antagonist of m1 receptors.
S I, Max, J S, Liang, H H, Valentine, L T, Potter   +3 more
openaire   +2 more sources

Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens

European Journal of Pharmacology, 1993
In the electrically field-stimulated rabbit vas deferens, muscarinic receptor agonists increase twitch-height by actions at postjunctional M2 receptors and decrease twitch-height by actions at prejunctional M1 receptors. In the present studies, in contrast to previous reports, muscarinic receptor agonists primarily decreased twitch-height, produced ...
Frank P. Bymaster, Harlan E. Shannon, Barry D. Sawyer, John S. Ward, Charles H. Mitch, Ian Heath, Kerry G. Bemis   +6 more
openaire   +3 more sources

Stable allosteric binding of m1-toxin to m1 muscarinic receptors.

Molecular Pharmacology, 1993
m1-Toxin was found to slow the dissociation of [3H]N-methyl-scopolamine (NMS) and [3H]pirenzepine from m1 muscarinic receptors expressed in the membranes of Chinese hamster ovary cells. When toxin-NMS-receptor complexes were formed in membranes and then dissolved in digitonin, or when these complexes were formed in solution, the toxin completely ...
S I, Max, J S, Liang, L T, Potter
openaire   +2 more sources

Disinhibition in the rat septum mediated by M1 muscarinic receptors

Brain Research, 1988
Acetylcholine (ACh) has been documented as an important central neurotransmitter. We have investigated the actions of ACh within the dorsolateral septal nucleus of the rat to examine its actions within this nucleus, specifically how it may interact to modulate the inhibitory action of gamma-aminobutyric acid (GABA), the known inhibitory transmitter in ...
Joel P. Gallagher, Patricia Shinnick-Gallagher, Hiroshi Hasuo   +2 more
openaire   +3 more sources

M1 muscarinic receptor signaling in mouse hippocampus and cortex

Brain Research, 2002
The five subtypes (M1-M5) of muscarinic acetylcholine receptors signal through G(alpha)(q) or G(alpha)(i)/G(alpha)(o). M1, M3 and M5 receptors couple through G(alpha)(q) and function predominantly as postsynaptic receptors in the central nervous system.
Neil W. DeLapp, Masahisa Yamada, Christian C. Felder, Jürgen Wess, Neil M. Nathanson, Frank P. Bymaster, Susan E. Hamilton, Amy C. Porter   +7 more
openaire   +3 more sources

Novel persistent activation of muscarinic M1 receptors by xanomeline

European Journal of Pharmacology, 1997
The muscarinic agonists, xanomeline and carbachol, displayed similar intrinsic activities in stimulating neuronal nitric oxide synthase at muscarinic M1 receptors in Chinese hamster ovary (CHO) cells, with xanomeline being more potent. Pre-incubation (1 h) with 1 microM xanomeline, followed by extensive washing, resulted in a significantly elevated ...
Esam E. El-Fakahany, Arthur Christopoulos   +1 more
openaire   +3 more sources