Results 91 to 100 of about 8,456 (200)

Regulation of Src family kinases by muscarinic acetylcholine receptors in heterologous cells and neurons

Frontiers in Molecular Neuroscience
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao, Lexi Young, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +4 more
doaj   +1 more source

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, Volume 182, Issue 19, Page 4625-4646, October 2025.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets

Cellular Physiology and Biochemistry, 2014
Background/ Aims: Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide public health burdens.
Rosiane A. Miranda, Aryane R. Agostinho, Isis H. Trevenzoli, Luiz F. Barella, Claudinéia C. S. Franco, Amanda B. Trombini, Ananda Malta, Clarice Gravena, Rosana Torrezan, Paulo C. F. Mathias, Júlio C. de Oliveira   +10 more
doaj   +1 more source

Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ. [PDF]

PLoS ONE, 2015
Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound healing. Neuropeptides and neurotransmitters are usually associated with neuronal signaling, but have recently been shown to be produced also by non-neuronal ...
Marta Słoniecka, Sandrine Le Roux, Peter Boman, Berit Byström, Qingjun Zhou, Patrik Danielson   +5 more
doaj   +1 more source

The Neuropathology of Alcohol Use Disorder: Cellular Insights From Human Post‐Mortem Studies

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
Major cellular changes in alcohol use disorder human post‐mortem brain. Alcohol use disorder (AUD) is a complex neurological disorder that undergoes neural changes, mainly degeneration and or cellular alterations impacting addiction behaviours. Key brain regions implicated in AUD are the cortex, striatum, corpus callosum, hippocampus, hypothalamus ...
Ameer E. Rasool, Jennifer L. Cornish, Asheeta A. Prasad   +2 more
wiley   +1 more source

Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.

PLoS ONE, 2019
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter, Laura Klein, Christin Helmschrodt, Angelika Richter   +3 more
doaj   +1 more source

Variability in the Drug Response of M4 Muscarinic Receptor Knockout Mice During Day and Night Time

Frontiers in Pharmacology, 2019
Mice are nocturnal animals. Surprisingly, the majority of physiological/pharmacological studies are performed in the morning, i.e., in the non-active phase of their diurnal cycle.
Paulina Valuskova, Vladimir Riljak, Sandor T. Forczek, Vladimir Farar, Jaromir Myslivecek   +4 more
doaj   +1 more source

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor [PDF]

, 2014
Background: BQCA is a selective allosteric modulator of the M1 mAChR. Results: Residues that govern BQCA activity were identified using mutagenesis and molecular modelling.
Abdul-Ridha, Avlani, Ballesteros, Black, Canals, Cherezov, Choe, Christopoulos, Conn, Conn, Daval, Davie, De Amici, Dror, Duan, Goodwin, Haga, Huang, Hulme, Hulme, Kenakin, Kruse, Lagerström, Leach, Leach, Leach, Lebois, Lebon, Lu, Lu, Ma, Marquer, Matsui, May, May, Miao, Mistry, Motulsky, Nawaratne, Nawaratne, Phillips, Prilla, Rasmussen, Rasmussen, Sali, Shirey, Shonberg, Spalding, Stevens, Tan, Thompson, Valant, Valant, Valentin-Hansen, Venkatakrishnan, Voigtländer, Wacker, Wang   +57 more
core   +2 more sources

Oral Adverse Effects of Antipsychotic Medications: A Case/Noncase Analysis of EudraVigilance Data

Oral Diseases, Volume 31, Issue 8, Page 2630-2640, August 2025.
ABSTRACT Objective Neuropsychiatric disorders are associated with poor oral health, with antipsychotics as potential contributors. This study aimed to analyse the oral adverse effects of antipsychotics using the EudraVigilance database. Methods A case/noncase analysis was conducted to calculate reporting odds ratios (ROR) and assess the ...
Leire Urien, Unax Lertxundi, Montserrat Garcia, Carmelo Aguirre, Nerea Jauregizar, Teresa Morera‐Herreras   +5 more
wiley   +1 more source

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

BMC Cell Biology, 2005
Background Recent studies indicate that the G protein-coupled receptor (GPCR) signaling machinery can serve as a direct target of reactive oxygen species, including nitric oxide (NO) and S-nitrosothiols (RSNOs).
Mönkkönen Kati S, Savinainen Juha R, Kokkola Tarja, Retamal Montse, Laitinen Jarmo T   +4 more
doaj   +1 more source