Results 101 to 110 of about 8,456 (200)

Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling [PDF]

, 2017
Satiety, rather than all or none, can instead be viewed as a cumulative decrease in the drive to eat that develops over the course of a meal. The nucleus accumbens (NAc) is known to play a critical role in this type of value reappraisal, but the ...
Aitta-aho, Teemu Heikki Juhani, Apergis-Schoute, John, Bussey, Tim J., Harnischfeger, Fiona, Hay, Y. Adrey, Heath, Christopher, Pappa, Elpiniki, Phillips, Benjamin U., Saksida, Lisa M.   +8 more
core   +2 more sources

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
core   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

Frontiers in Molecular Neuroscience, 2018
The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive.
Anna M. Klawonn, Anna M. Klawonn, Daniel B. Wilhelms, Daniel B. Wilhelms, Sarah H. Lindström, Anand Kumar Singh, Anand Kumar Singh, Maarit Jaarola, Jürgen Wess, Michael Fritz, Michael Fritz, David Engblom   +11 more
doaj   +1 more source

Positive allosteric modulation of the muscarinic M1 receptor improves efficacy of antipsychotics in mouse glutamatergic deficit models of behavior [PDF]

, 2016
Current antipsychotics are effective in treating the positive symptoms associated with schizophrenia, but they remain suboptimal in targeting cognitive dysfunction.
Arthur Christopoulos, Bakshi, Christopher J. Langmead, Christos Pantelis, Daniel T. Malone, David M. Shackleford, Johnathan R. Lane, Kwok H. C. Choy, Lee, Matsuo, Pantelis, Patrick M. Sexton, Peter J. Scammells, Rahul T. Patil, Shailesh N. Mistry   +14 more
core   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia

Frontiers in Psychiatry
Cognitive impairment is a core symptom of schizophrenia and a major determinant of poor long-term functional outcomes. Despite considerable efforts, we do not yet have any approved pharmacological treatments for cognitive impairment associated with ...
Samantha E. Yohn, Phillip D. Harvey, Stephen K. Brannan, William P. Horan, William P. Horan   +4 more
doaj   +1 more source

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit [PDF]

, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Acsády, Ahumada, Aizawa, Akam, Alkondon, Andrade, Andrade, Aznar, Bacon, Barnes, Beck, Berumen, Bijak, Bliss, Bombardi, Brandalise, Bronzino, Buchanan, Bush, Cezar M. Tigaret, Chalmers, Chandler, Cheng, Chiang, Contractor, Cox, Danielson, Dasari, Domínguez, Domínguez, Donato, Etter, Fabian-Fine, Fischer, Frazier, Freund, Fuhs, Fukudome, Gahring, Gahring, Gangarossa, Gasbarri, Gasbarri, Gelinas, Gelinas, Giessel, Ginsberg, Giocomo, Goutagny, Gray, Griffith, Grishin, Grishin, Grybko, Grybko, Gulyás, Gundlfinger, Gundlfinger, Guo, Guzman, Haas, Haas, Hamilton, Hansen, Hansen, Hasselmo, Hasselmo, Hebb, Hofmann, Hofmann, Hofmann, Hopkins, Hopkins, Hu, Huang, Hummos, Hunsaker, Hunsaker, Hájos, Hörtnagl, Jack R. Mellor, Jacobs, Jerman, Jochems, Jochems, John, Jones, Jung, Jurgens, Karunakaran, Katsuki, Kheirbek, Kitt, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Kulla, Kunec, Kwon, Lacaille, Lee, Lemon, Lengyel, Lengyel, Leranth, Leutgeb, Levey, Li, Liotta, Lisman, Lisman, Losonczy, Luke Y. Prince, Luo, Lynch, Lüscher, Maccaferri, Madison, Madison, Maeda, Manuel-Apolinar, Marr, Martinello, Marín-Burgin, McHugh, McIntyre, McMahon, McNaughton, McQuiston, Meeter, Meeter, Millan, Milner, Milner, Mishra, Missale, Mistry, Miyawaki, Mlinar, Mohler, Mori, Mori, Müller, Nahir, Nakashiba, Nakashiba, Nakazawa, Nissen, Nolan, Nozaki, O'Reilly, Okuhara, Ondrejcak, Parfitt, Parfitt, Pazos, Pedarzani, Pelkey, Piguet, Puighermanal, Radcliffe, Ramos, Restivo, Romo-Parra, Rosen, Ruediger, Ruiz, Rüdiger, Salin, Sara, Saravanan, Sariñana, Savin, Scanziani, Scanziani, Scoville, Segal, Sharma, Sharma, Smith, Sodickson, Son, Squire, Straube, Suwa, Szabadics, Szabó, Takeuchi, Tang, Tigaret, Torborg, Toth, Travis J. Bacon, Treves, Treviño, Twarkowski, Tzounopoulos, Törk, Ul Haq, Ul Haq, Vankov, Varga, Vilaró, Vilaró, Villani, Vogels, Vogt, Walling, Walling, Wang, Welsby, Welsby, West, Wiescholleck, Wilke, Williams, Williams, Yang, Yi, Zalutsky, Zhang   +221 more
core   +5 more sources

Activation of Muscarinic Acetylcholine Receptor Subtype 4 is Essential for Cholinergic Stimulation of Gastric Acid Secretion - Relation To D Cell/Somatostatin -

Frontiers in Pharmacology, 2016
Background/Aim: Muscarinic acetylcholine receptors exist in five subtypes (M1~M5), and they are widely expressed in various tissues to mediate diverse autonomic functions, including gastric secretion.
Koji Takeuchi, Koji Takeuchi, Takuya Endoh, Shusaku Hayashi, Takeshi Aihara   +4 more
doaj   +1 more source