Results 121 to 130 of about 8,456 (200)

UEG Week 2025 Poster Presentations

United European Gastroenterology Journal, Volume 13, Issue S8, Page S803-S1476, October 2025.
wiley   +1 more source

Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor [PDF]

ACS Medicinal Chemistry Letters, 2017
openaire   +4 more sources

Genetic linkage mapping of the m4 human muscarinic receptor (CHRM4) [PDF]

Genomics, 1992
R P, Grewal, M, Martinez, M, Hoehe, T I, Bonner, E S, Gershon, S, Detera-Wadleigh   +5 more
openaire   +2 more sources

Is anti-cholinesterase therapy of Alzheimer's disease delaying progression? [PDF]

, 2018
During the last decade, a systematic effort to develop a pharmacological treatment for Alzheimer's disease (AD) resulted in three drugs being registered for the first time in the US and Europe.
Giacobini, E.
core  

Muscarinic Acetylcholine Receptor M4 [PDF]

, 2020
openaire   +1 more source

CHANGES IN MOTOR ACTIVITY IN FEMALE MICE LACKING M4 MUSCARINIC RECEPTOR AFTER OVARIECTOMY

IBRO Neuroscience Reports, 2023
Katerina Janisova, Jaromir Myslivecek, Monika Krizova   +2 more
doaj   +1 more source

Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approved, 2 approved with reservations]

F1000Research
Background Muscarinic receptor agonism and positive allosteric modulation is a promising mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics.
Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod   +21 more
doaj   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Muscarinic acetylcholine receptor M4 (CHRM4; HM4) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Associations between functional autoantibodies targeting GPCRs, antinuclear antibodies, and inflammatory cytokines TNF-α: a cross-sectional study of 19,810 individuals. [PDF]

Front Immunol
Chen X, Kieselbach B, Krämer BK, von Baehr V, Reichetzeder C, Hocher B.   +5 more
europepmc   +1 more source