Results 181 to 190 of about 8,456 (200)
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Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients
Brain Research, 2003We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, M(4) selective).
Mulugeta E +6 more
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Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors
European Journal of Pharmacology, 1999Available evidence indicates that the antipsychotic drug clozapine acts as a partial agonist at the muscarinic M4 and as an antagonist at the M2 receptors. We wondered whether there is indeed a fundamental difference between its action on these two receptor subtypes, and whether it interacts with their classical or allosteric binding sites.
P, Michal +3 more
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Muscarinic M4 receptors regulate GABAergic transmission in rat tuberomammillary nucleus neurons
Neuropharmacology, 2012Histaminergic neurons within the tuberomammillary nucleus (TMN) play an important role in sleep-wakefulness regulation. Here, we report the muscarinic modulation of GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) in mechanically dissociated rat histaminergic neurons using a conventional whole-cell patch clamp technique ...
Michiko, Nakamura, Il-Sung, Jang
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Muscarinic toxin selective for m4 receptors impairs memory in the rat
NeuroReport, 1998The selectivity of the muscarinic toxin MT3 from green mamba snake venom was corroborated by inhibition of the binding of [3H]NMS, a classical muscarinic radioligand, to native and cloned muscarinic receptors, showing 214-fold higher affinity for m4 than for m1 subtype, without significant binding to the others. The highest concentrations of MT3 sites (
D, Jerusalinsky +7 more
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Interaction Studies of Multiple Binding Sites on M4 Muscarinic Acetylcholine Receptors
Molecular Pharmacology, 2006This study investigated the reciprocal cross-interactions between two distinct allosteric sites on the M(4) muscarinic acetylcholine receptor (mAChR) in the absence or presence of different orthosteric ligands. Initial studies revealed that two novel benzimidazole allosteric modulators, 17-beta-hydroxy-17-alpha-ethy nyl-delta(4)-androstano[3,2-b ...
Alfred A, Lanzafame +2 more
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Muscarinic M4 receptor inhibition of dopamine D1-like receptor signalling in rat nucleus accumbens
European Journal of Pharmacology, 2002Several studies have indicated the occurrence of an antagonistic interaction between muscarinic and dopamine D1-like receptors in the ventral striatum, but the subtype(s) of muscarinic receptor involved has not been characterized. We show that in membranes of rat nucleus accumbens, carbachol inhibited the stimulation of adenylyl cyclase activity by ...
ONALI, PIER LUIGI +1 more
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Brain Research, 2001
The striatum has nearly equal numbers of striatonigral and striatopallidal projection neurons. All are GABAergic and inhibitory, but they lie in separate neuronal circuits ('direct' and 'indirect', respectively) that appear to exert opposite effects on movement. Methods are needed to evaluate the function of each circuit.
M P, Santiago, L T, Potter
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The striatum has nearly equal numbers of striatonigral and striatopallidal projection neurons. All are GABAergic and inhibitory, but they lie in separate neuronal circuits ('direct' and 'indirect', respectively) that appear to exert opposite effects on movement. Methods are needed to evaluate the function of each circuit.
M P, Santiago, L T, Potter
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Molecular Pharmacology, 1996
We analyzed the role of receptor internalization and recycling in muscarinic acetylcholine receptor (mAChR) desensitization and resensitization. Incubation of Chinese hamster ovary cells stably expressing the m4 mAChR with 1 mM carbachol for 1 hr reduced cell surface receptor number by 50-60% with no change in total receptor number. Pretreatment of the
G S, Bogatkewitsch +3 more
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We analyzed the role of receptor internalization and recycling in muscarinic acetylcholine receptor (mAChR) desensitization and resensitization. Incubation of Chinese hamster ovary cells stably expressing the m4 mAChR with 1 mM carbachol for 1 hr reduced cell surface receptor number by 50-60% with no change in total receptor number. Pretreatment of the
G S, Bogatkewitsch +3 more
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M4 Muscarinic Acetylcholine Receptor Modulation of Dopamine Receptor Functions
2017M4 muscarinic acetylcholine receptors (mAChRs) belong to the Rhodopsin family of G protein-couple receptors. These receptors are found most abundantly in the striatum and are implicated in a number of central nervous system disorders, including schizophrenia.
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Contraction of guinea-pig gallbladder: muscarinic M3 or M4 receptors?
European Journal of Pharmacology, 1997The muscarinic receptor mediating contraction of the guinea-pig isolated gallbladder, currently being disputed to belong either to the M3 or M4 subtype, was characterized by subtype-preferring agonists and discriminating antagonists. Highly significant correlations of agonist potencies to contract the gallbladder, e.g., arecaidine propargyl ester ...
M, Eltze +3 more
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