Results 191 to 200 of about 8,456 (200)
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Life Sciences, 1999
In membranes of Chinese hamster ovary cells expressing the cloned human M1-M4 muscarinic receptor subtypes, PD 102807, a novel M4 selective antagonist, was found to counteract the M4 receptor-induced stimulation of [35S]-GTPgammaS binding to membrane G proteins with a pK(B) of 7.40, a value which was 63-, 33- and 10-fold higher than those displayed at ...
OLIANAS, MARIA CONCETTA +1 more
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In membranes of Chinese hamster ovary cells expressing the cloned human M1-M4 muscarinic receptor subtypes, PD 102807, a novel M4 selective antagonist, was found to counteract the M4 receptor-induced stimulation of [35S]-GTPgammaS binding to membrane G proteins with a pK(B) of 7.40, a value which was 63-, 33- and 10-fold higher than those displayed at ...
OLIANAS, MARIA CONCETTA +1 more
openaire +3 more sources
Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice
European Journal of Pharmacology, 2015Modulation of cholinergic neurotransmission via nicotinic acetylcholine receptors is known to alter alcohol-drinking behavior. It is not known if muscarinic acetylcholine receptor subtypes have similar effects. The muscarinic M4 receptor is highly expressed in the brain reinforcement system and involved in regulation of cholinergic and dopaminergic ...
de la Cour, Cecilie +6 more
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Use of Antimuscarinic Toxins To Facilitate Studies of Striatal m4 Muscarinic Receptors
The Journal of Pharmacology and Experimental Therapeutics, 1998Striatal m4 muscarinic receptors are important because their blockade controls movement, and they are preferentially located on striatal neurons that project to the internal globus pallidus. The following studies were performed in vitro to provide a basis for using antimuscarinic toxins to study the effects of selective m4 blockade on movement in vivo.
S L, Purkerson, L T, Potter
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Muscarinic M4 Receptor Recycling Requires a Motif in the Third Intracellular Loop
The Journal of Pharmacology and Experimental Therapeutics, 2008The present study was performed to identify sequence(s) in the third intracellular loop (i3) of the muscarinic acetylcholine receptor M4 subtype (M4 receptor) involved in its internalization and recycling. In transiently transfected human embryonic kidney 293-tsA201 cells, 40 to 50% of cell-surface M4 receptors are internalized in an agonist-dependent ...
Yuichi, Hashimoto +5 more
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A new cholinergic mechanism for antipsychotics: emraclidine and M4 muscarinic receptors
The Lancet, 2022John, Cookson, Ferdinand, Jonsson
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Structure-function studies of M4 muscarinic acetylcholine receptor allosteric modulation
2017The M4 muscarinic acetylcholine receptor (mAChR) is implicated in many central nervous system disorders, however, due to a highly conserved acetylcholine (ACh) binding orthosteric site, there is a lack of highly selective ligands as therapeutics and experimental probes for this target.
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Rat dorsal root ganglia express m1-m4 muscarinic receptor proteins.
Journal of the peripheral nervous system : JPNS, 2000The distribution of m1-m4 muscarinic acetylcholine receptors was investigated by immunolight and electron microscopy in rat dorsal root ganglia, by using subtype-specific antibodies. The light microscopic observations show that both the intensity and the localisation of immunolabeling of the four muscarinic subtypes are different.
N, Bernardini +2 more
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Centrally-Acting Antagonist of Muscarinic M4 Receptors
Emerging Therapeutic Targets, 1997openaire +1 more source
Altered distribution of M2 and M4 muscarinic receptor expression in vitiligo
The Journal of Dermatology, 2010Sirintip, Chaichalotornkul +4 more
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