Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan +6 more
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Platelet-Derived Growth Factor Receptor Beta [PDF]
Definitions, 2020 Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.
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Platelet-derived growth factor receptor beta: a novel urinary biomarker for recurrence of non-muscle-invasive bladder cancer. [PDF]
PLoS ONE, 2014 Non-muscle-invasive bladder cancer (NMIBC) is one of the most common malignant tumors in the urological system with a high risk of recurrence, and effective non-invasive biomarkers for NMIBC relapse are still needed.
Jiayu Feng +8 more
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Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression [PDF]
Molecular and Cellular Biology, 2000 Platelet-derived growth factor BB (PDGF BB) is a potent mitogen for fibroblasts as well as many other cell types. Interaction of PDGF BB with the PDGF β receptor (PDGF-βR) activates numerous signaling pathways and leads to a decrease in receptor ...
S. Oster +8 more
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Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. [PDF]
PLoS ONE, 2010 Platelet-derived growth factor receptor beta (PDGFRbeta) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, yet the role of PDGF signaling has not ...
Katie M Wiens +5 more
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Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. [PDF]
Proceedings of the National Academy of Sciences, 1994 Protein-tyrosine-phosphatase SHPTP2 (Syp/PTP-1D/PTP2C) is the homologue of the Drosophila corkscrew (csw) gene product, which transmits positive signals from receptor tyrosine kinases.
A. Bennett +4 more
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Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy [PDF]
Frontiers in Molecular BiosciencesPlatelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skeletal ...
Insan Habib +8 more
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The Journal of Immunology, 1993 Platelet-derived growth factor (PDGF) is thought to play a significant role in bone repair and regeneration. We previously demonstrated that PDGF-AA-induced chemotaxis and proliferation can be modulated by IL-1.
Y. Yeh +4 more
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GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex
Biomolecules, 2023 Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis.
Baikang Xie +7 more
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Isolation and characterization of the platelet-derived growth factor beta receptor promoter [PDF]
Developmental Dynamics, 1997 The PDGFbeta r gene has been implicated in many physiological processes including development and wound healing. Aberrant expression of the receptor is seen in many pathological conditions such as atherosclerosis and inflammatory diseases. To study the mechanisms of PDGFbeta r regulation, we identified the regulatory regions of the gene. We have cloned
Eve Shinbrot +2 more
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