Results 1 to 10 of about 81,730 (158)
Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events.
Ming Tan +6 more
doaj +3 more sources
Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. [PDF]
PLoS ONE, 2010 Platelet-derived growth factor receptor beta (PDGFRbeta) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, yet the role of PDGF signaling has not ...
Katie M Wiens +5 more
doaj +5 more sources
PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. [PDF]
, 2014 Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often ...
Abbott, Nicholas +11 more
core +26 more sources
Stem Cell Research, 2023 PDGFRB encodes platelet-derived growth factor receptor beta (PDGFR-β), a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
Seongyea Jo +5 more
doaj +1 more source
GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex
Biomolecules, 2023 Growth differentiation factor-15 (GDF-15) is proposed to be strongly associated with several cardiovascular diseases, such as heart failure and atherosclerosis.
Baikang Xie +7 more
doaj +1 more source
Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation [PDF]
Journal of Biological Chemistry, 2021 Abl family kinases are nonreceptor tyrosine kinases activated by diverse cellular stimuli that regulate cytoskeleton organization, morphogenesis, and adhesion. The catalytic activity of Abl family kinases is tightly regulated in cells by a complex set of intramolecular and intermolecular interactions and post-translational modifications.
Kuanlin Wu +6 more
openaire +2 more sources
Platelet-derived growth factor receptor-β in Gorham's disease [PDF]
Nature Clinical Practice Oncology, 2006 A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass
Jeroen, Hagendoorn +11 more
openaire +2 more sources
The Journal of Pathology: Clinical Research, 2021 Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties and interplay of MPM tumor cells and their surrounding stromal fibroblasts are poorly characterized.
Hely Ollila +13 more
doaj +1 more source
Peptide-Based Targeting of the Platelet-Derived Growth Factor Receptor Beta [PDF]
Molecular Imaging and Biology, 2012 The aim of this work is to identify new ligands targeting the platelet-derived growth factor receptor beta (PDGFRβ).Biopanning was carried out with a 12-amino-acid phage display library against the recombinant extracellular domain of PDGFRβ. The identified peptide PDGFR-P1 was chemically synthesized and labeled with (125)I or (131)I.
Askoxylakis, Vasileios +7 more
openaire +2 more sources
Isolation and characterization of the platelet-derived growth factor beta receptor promoter [PDF]
Developmental Dynamics, 1997 The PDGFbeta r gene has been implicated in many physiological processes including development and wound healing. Aberrant expression of the receptor is seen in many pathological conditions such as atherosclerosis and inflammatory diseases. To study the mechanisms of PDGFbeta r regulation, we identified the regulatory regions of the gene. We have cloned
E, Shinbrot, X, Liao, L T, Williams
openaire +2 more sources