Results 1 to 10 of about 79,551 (79)
Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events. Therefore, we aimed to investigate the levels of miR-223, miR-339 and miR-21 in plasma exosomes before thrombosis in mouse models of carotid ...
Wen Chen +6 more
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Platelet-Derived Growth Factor Receptor Beta [PDF]
Definitions, 2020 Platelet-derived growth factor receptor beta (1106 aa, ~124 kDa) is encoded by the human PDGFRB gene. This protein plays a role in tyrosine phosphorylation and ligand-dependent signal transduction.
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Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression [PDF]
Molecular and Cellular Biology, 2000 Platelet-derived growth factor BB (PDGF BB) is a potent mitogen for fibroblasts as well as many other cell types. Interaction of PDGF BB with the PDGF beta receptor (PDGF-betaR) activates numerous signaling pathways and leads to a decrease in receptor expression on the cell surface.
Sara K. Oster +11 more
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Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. [PDF]
Proceedings of the National Academy of Sciences, 1994 Protein-tyrosine-phosphatase SHPTP2 (Syp/PTP-1D/PTP2C) is the homologue of the Drosophila corkscrew (csw) gene product, which transmits positive signals from receptor tyrosine kinases. Likewise, SHPTP2 has been implicated in positive signaling from platelet-derived growth factor receptor beta (PDGFR).
Christopher T. Walsh +4 more
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The Journal of Immunology, 1993 Abstract Platelet-derived growth factor (PDGF) is thought to play a significant role in bone repair and regeneration. We previously demonstrated that PDGF-AA-induced chemotaxis and proliferation can be modulated by IL-1. We now report that IL-1 and transforming growth factor-beta (TGF-beta) significantly decrease the number of PDGF-AA ...
Y L, Yeh +4 more
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Isolation and characterization of the platelet-derived growth factor beta receptor promoter [PDF]
Developmental Dynamics, 1997 The PDGFbeta r gene has been implicated in many physiological processes including development and wound healing. Aberrant expression of the receptor is seen in many pathological conditions such as atherosclerosis and inflammatory diseases. To study the mechanisms of PDGFbeta r regulation, we identified the regulatory regions of the gene. We have cloned
Eve Shinbrot +2 more
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Peptide-Based Targeting of the Platelet-Derived Growth Factor Receptor Beta [PDF]
Molecular Imaging and Biology, 2012 The aim of this work is to identify new ligands targeting the platelet-derived growth factor receptor beta (PDGFRβ).Biopanning was carried out with a 12-amino-acid phage display library against the recombinant extracellular domain of PDGFRβ. The identified peptide PDGFR-P1 was chemically synthesized and labeled with (125)I or (131)I.
Jürgen Debus +7 more
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Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation [PDF]
Journal of Biological Chemistry, 2021 Abl family kinases are nonreceptor tyrosine kinases activated by diverse cellular stimuli that regulate cytoskeleton organization, morphogenesis, and adhesion. The catalytic activity of Abl family kinases is tightly regulated in cells by a complex set of intramolecular and intermolecular interactions and post-translational modifications.
Kuanlin Wu +6 more
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Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB. [PDF]
Journal of Biological Chemistry, 1991 We describe that stimulation of human fibroblasts with platelet-derived growth factor BB (PDGF-BB) induces a transient up-regulation of the PDGF alpha- and beta-receptor transcript and protein levels. The effect of PDGF-BB on the receptor transcript levels was more pronounced than those seen when other cytokines were used.
Lena Claesson-Welsh +5 more
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Platelet-derived growth factor receptor-β in Gorham's disease [PDF]
Nature Clinical Practice Oncology, 2006 A 17-year-old male presented with pain in his lower-left chest. He had no significant medical history and was previously in good health. He had a fractured ninth left anterior rib and the tenth, eleventh and twelfth ribs were absent, which was thought to be a congenital anomaly. Several months later, he presented again with back pain, an enlarging mass
Andrew E. Rosenberg +11 more
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