Results 81 to 90 of about 79,696 (126)

Identification of potential bioactive phytochemicals for the inhibition of platelet-derived growth factor receptor β: a structure-based approach for cancer therapy

Frontiers in Molecular Biosciences
Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the receptor tyrosine kinase (RTK) protein family and is implicated in several disorders such as hematopoietic, glial, and soft-tissue cancer, non-cancerous disorders, including skeletal ...
Insan Habib, Insan Habib, Md Nayab Sulaimani, Deeba Shamim Jairajpuri, Afzal Hussain, Taj Mohammad, Mohamed F. Alajmi, Anas Shamsi, Md Imtaiyaz Hassan   +8 more
doaj   +1 more source

Targets and Candidate Agents for Type 2 Diabetes Treatment with Computational Bioinformatics Approach

Journal of Diabetes Research, 2014
We sought to explore the molecular mechanism of type 2 diabetes (T2D) and identify potential drug targets and candidate agents for T2D treatment. The differentially expressed genes (DEGs) were assessed between human pancreatic islets with T2D and normal ...
Qiong Wang, Zhigang Zhao, Jing Shang, Wei Xia   +3 more
doaj   +1 more source

Immune thrombocytopenia is associated with persistently deranged fibrosis-related seromarker profiles but low bone marrow fibrosis grades: A 2-year observational study on thrombopoietin receptor agonist treatment

Platelets, 2019
Bone marrow (BM) fibrosis is a potential side effect of thrombopoietin receptor agonist (TPO-RA) treatment. We aimed to investigate stromal seromarker profiles and growth factors in order to elucidate pathogenic and dynamic aspects of immune ...
Waleed Ghanima, Leonardo Boiocchi, Christina S. Lee, Xingmin Feng, Julia Turbiner Geyer, Sif Gudbrandsdottir, Attilio Orazi, Peter Junker, James B. Bussel   +8 more
doaj   +1 more source

A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver diseaseResearch in context

EBioMedicine, 2019
Background: Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. Methods:
Joeri Lambrecht, Stefaan Verhulst, Inge Mannaerts, Jan-Peter Sowa, Jan Best, Ali Canbay, Hendrik Reynaert, Leo A. van Grunsven   +7 more
doaj  

Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer

International Journal of Women's Health, 2014
Brittany A Davidson, Angeles Alvarez Secord Division of Gynecologic Oncology, Duke Cancer Institute, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA Abstract: Epithelial ovarian cancer (EOC) is the most lethal ...
Davidson BA, Secord AA
doaj  

A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line

Molecular and Cellular Biology, 1992
M. Eccles, F. King, M. Cole
semanticscholar   +1 more source

Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genes

Drug Design, Development and Therapy, 2017
Ali Kadivar,1 Behnam Kamalidehghan,1 Hamid Akbari Javar,2 Benyamin Karimi,3 Reihaneh Sedghi,4 Mohamed Ibrahim Noordin1 1Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; 2Department of Pharmaceutics, Faculty of ...
Kadivar A, Kamalidehghan B, Akbari Javar H, Karimi B, Sedghi R, MI Noordin   +5 more
doaj  

Cerebrospinal fluid platelet-derived growth factor receptor-beta is negatively correlated with depressive symptom severity in suicide attempters

Journal of Affective Disorders Reports
Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity.
A. Bontidean, D. Lindqvist, C. Grudet, L. Träskman-Bendz, L. Brundin, F. Ventorp   +5 more
doaj  

Drug-Induced Reorganisation of Lipid Metabolism Limits the Therapeutic Efficacy of Ponatinib in Glioma Stem Cells

Pharmaceutics
The standard of care for glioblastoma (GBM) involves surgery followed by adjuvant radio- and chemotherapy, but often within months, patients relapse, and this has been linked to glioma stem cells (GSCs), self-renewing cells with increased therapy ...
Paula Aldaz, Ana Olias-Arjona, Irene Lasheras-Otero, Karina Ausin, Marta Redondo-Muñoz, Claudia Wellbrock, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Imanol Arozarena   +8 more
doaj   +1 more source

Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage

iScience
Summary: White adipose tissue (WAT) development and adult homeostasis rely on distinct adipocyte progenitor cells (APCs). While adult APCs are defined early during embryogenesis and generate adipocytes after WAT organogenesis, the mechanisms underlying ...
Abigail M. Benvie, Derek Lee, Yuwei Jiang, Daniel C. Berry   +3 more
doaj