Results 1 to 10 of about 214,894 (274)
Insights into intercellular receptor-ligand binding kinetics in cell communication [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Cell-cell communication is crucial for cells to sense, respond and adapt to environmental cues and stimuli. The intercellular communication process, which involves multiple length scales, is mediated by the specific binding of membrane-anchored receptors
Chenyi An +6 more
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Dimensionality of Motion and Binding Valency Govern Receptor–Ligand Kinetics As Revealed by Agent-Based Modeling [PDF]
Frontiers in Immunology, 2017 Mathematical modeling and computer simulations have become an integral part of modern biological research. The strength of theoretical approaches is in the simplification of complex biological systems.
Teresa Lehnert +4 more
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Receptor-Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands. [PDF]
ACS Chem Biol, 2021 Kimani FW +6 more
europepmc +3 more sources
Multicolored sequential resonance energy transfer for detection of simultaneous ligand binding at G protein-coupled receptors [PDF]
Nature CommunicationsG protein coupled-receptors (GPCRs) are the largest family of signalling proteins and highly successful drug targets. Most GPCR targeting drugs interact with a binding pocket for the natural ligand of the receptor, typically near the extracellular region
Alice Valentini +12 more
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Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell. [PDF]
J Vis Exp, 2015 Chen Y +6 more
europepmc +3 more sources
Frontiers in Molecular Biosciences, 2023 The kinetics of a ligand-receptor interaction determine the responses of the receptor-expressing cell. One approach to experimentally and reversibly change this kinetics on demand is optogenetics.
Marissa Russ +17 more
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Open Biology, 2022 M4 muscarinic acetylcholine receptor is a G protein-coupled receptor (GPCR) that has been associated with alcohol and cocaine abuse, Alzheimer's disease, and schizophrenia which makes it an interesting drug target.
Maris-Johanna Tahk +10 more
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A tunable coarse-grained model for ligand-receptor interaction. [PDF]
PLoS Computational Biology, 2013 Cell-surface receptors are the most common target for therapeutic drugs. The design and optimization of next generation synthetic drugs require a detailed understanding of the interaction with their corresponding receptors. Mathematical approximations to
Teresa Ruiz-Herrero +4 more
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Frontiers in Molecular Biosciences, 2023 Dopamine receptors are G-protein-coupled receptors that are connected to severe neurological disorders. The development of new ligands targeting these receptors enables gaining a deeper insight into the receptor functioning, including binding mechanisms,
Maris-Johanna Tahk +10 more
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Two-dimensional measurements of receptor-ligand interactions
Frontiers in Molecular Biosciences, 2023 Gaining insight into the two-dimensional receptor-ligand interactions, which play a significant role in various pivotal biological processes such as immune response and cancer metastasis, will deepen our understanding of numerous physiological and ...
Songjie Zheng +7 more
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