Results 11 to 20 of about 118,083 (181)

Kinetic tools for the identification of ligand–receptor interaction mechanisms; pp 202–213 [PDF]

Proceedings of the Estonian Academy of Sciences, 2017
Tools for the identification of receptor–ligand interaction mechanisms were developed by mathematical modeling of the influence of a ligand on the kinetics of a reporter ligand binding with a receptor.
Siim Kukk, Peep Miidla, Jaak Järv
doaj   +1 more source

A minimal mathematical model for the initial molecular interactions of death receptor signalling

Mathematical Biosciences and Engineering, 2012
Tumor necrosis factor (TNF) is the name giving member of a large cytokine family mirrored by a respective cell membrane receptor super family. TNF itself is a strong proinflammatory regulator of the innate immune system, but has been also recognized as a
Christian Winkel, Simon Neumann, Christina Surulescu, Peter Scheurich   +3 more
doaj   +1 more source

Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow

Theoretical and Applied Mechanics Letters, 2015
Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the ...
Yu Du, Shuang Peng, Yuhong Cui, Shouqin Lü, Yan Zhang, Mian Long   +5 more
doaj   +1 more source

Chemotaxis receptor complexes: from signaling to assembly. [PDF]

PLoS Computational Biology, 2007
Complexes of chemoreceptors in the bacterial cytoplasmic membrane allow for the sensing of ligands with remarkable sensitivity. Despite the excellent characterization of the chemotaxis signaling network, very little is known about what controls receptor ...
Robert G Endres, Joseph J Falke, Ned S Wingreen   +2 more
doaj   +1 more source

Binding kinetics of membrane-anchored receptors and ligands: molecular dynamics simulations and theory [PDF]

, 2015
The adhesion of biological membranes is mediated by the binding of membrane-anchored receptor and ligand proteins. Central questions are how the binding kinetics of these proteins is affected by the membranes and by the membrane anchoring of the proteins.
Hu, Jinglei, Lipowsky, Reinhard, Weikl, Thomas R., Xu, Guang-Kui   +3 more
core   +2 more sources

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [PDF]

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Aebischer, Toni, Blackburn, Clare, Brand, Janko, Brinkmann, Volker, Hoffmann, Kirstin, Lippuner, Christoph, Paape, Daniel, Paterou, Athina, Richardson, Melville, Smith, Andrew   +9 more
core   +1 more source

Notes on stochastic (bio)-logic gates: the role of allosteric cooperativity [PDF]

, 2014
Recent experimental breakthroughs have finally allowed to implement in-vitro reaction kinetics (the so called {\em enzyme based logic}) which code for two-inputs logic gates and mimic the stochastic AND (and NAND) as well as the stochastic OR (and NOR ...
Agliari, Elena, Altavilla, Matteo, Barra, Adriano, Katz, Evgeny, Schiavo, Lorenzo Dello   +4 more
core   +2 more sources

Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL

Frontiers in Cell and Developmental Biology, 2021
Tumor necrosis factor-associated ligand inducing apoptosis (TRAIL) induces apoptosis through the death receptors (DRs) 4 and 5 expressed on the cell surface. Upon ligand stimulation, death receptors are rapidly internalized through clathrin-dependent and
Artem A. Artykov, Anne V. Yagolovich, Anne V. Yagolovich, Dmitry A. Dolgikh, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Mikhail P. Kirpichnikov, Daria B. Trushina, Marine E. Gasparian   +8 more
doaj   +1 more source

Chemotactic response and adaptation dynamics in Escherichia coli [PDF]

, 2010
Adaptation of the chemotaxis sensory pathway of the bacterium Escherichia coli is integral for detecting chemicals over a wide range of background concentrations, ultimately allowing cells to swim towards sources of attractant and away from repellents ...
A Chalah, AN Barnakov, BA Mello, BA Mello, BA Mello, BA Mello, BW Andrews, CH Hansen, Christopher V. Rao, D Bray, D Chelsky, D Kentner, D Muzzey, DA Clark, DE Koshland, Diana Clausznitzer, EN Kort, EN Pugh Jr, GH Wadhams, GS Anand, HC Berg, HC Berg, J Spehr, J Wu, JE Keymer, JJ Falke, JP Goldman, L Zonia, Linda Løvdok, M Kollmann, M Li, M Li, M Li, MA Hilliard, MD Baker, MJ Jaasma, ML Skoge, ML Toews, N Barkai, N Vladimirov, N Vladimirov, Olga Oleksiuk, RG Endres, RG Endres, Robert G. Endres, SA Simms, SH Zigmond, T Emonet, T Gurry, T Ursell, T Yi, TAJ Duke, U Alon, V Sourjik, V Sourjik, V Sourjik, V Sourjik, Victor Sourjik, W Marwan, W Shi, WC Lai, WC Lai, Y Kalinin, Y Tu, YV Kalinin, Z Li   +65 more
core   +9 more sources

Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]

, 2014
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L., Deeni, Yusuf Y., Goltsov, Alexey, Harrison, David J., Hu, Huizhong, Khalil, Hilal S., Kyriakidis, Stylianos, Langdon, Simon P., Soininen, Tero   +8 more
core   +6 more sources