Results 21 to 30 of about 118,083 (181)

A computational model for understanding the oligomerization mechanisms of TNF receptor superfamily

Computational and Structural Biotechnology Journal, 2020
By recognizing members in the tumor necrosis factor (TNF) receptor superfamily, TNF ligand proteins function as extracellular cytokines to activate various signaling pathways involved in inflammation, proliferation, and apoptosis.
Zhaoqian Su, Yinghao Wu
doaj   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor I. Binding characteristics [PDF]

, 1994
Glimepiride is a novel sulfonylurea drug for treatment of non-insulin-dependent diabetes mellitus with higher blood sugar lowering efficacy in diabetic patients than glibenclamide raising the question whether this characteristics is in line with ...
Aguilar-Bryan, Ashcroft, Ashcroft, Benovic, Bhathena, Boyd, Boyd, Boyd, Carpentier, Chick, French, Gaines, Geisen, Geisen, Gerich, Gylfe, Kaubisch, Kolterman, Kramer, Kramer, Müller, Nelson, Nelson, Niki, Niki, Niki, Niki, Panten, Popov, Praz, Schmid-Antomarchi, Schmid-Antomarchi, Sturgess, Sugiura, Weiland, Yalow   +35 more
core   +1 more source

Quantification of the Cannabinoid Type 1 Receptor Availability in the Mouse Brain

Frontiers in Neuroanatomy, 2020
Introduction: The endocannabinoid system is involved in several diseases such as addictive disorders, schizophrenia, post-traumatic stress disorder, and eating disorders.
Isabelle Miederer, Viktoria Wiegand, Nicole Bausbacher, Petra Leukel, Stephan Maus, Manuela A. Hoffmann, Manuela A. Hoffmann, Beat Lutz, Beat Lutz, Mathias Schreckenberger   +9 more
doaj   +1 more source

Complete integrability of information processing by biochemical reactions [PDF]

, 2016
Statistical mechanics provides an effective framework to investigate information processing in biochemical reactions. Within such framework far-reaching analogies are established among (anti-) cooperative collective behaviors in chemical kinetics, (anti-)
Agliari, Elena, Barra, Adriano, Moro, Antonio, Schiavo, Lorenzo Dello   +3 more
core   +3 more sources

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation

Molecules, 2019
In this work we summarize our understanding of melanocortin 4 receptor (MC4R) pathway activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R.
Shubh Sharma, Alastair S. Garfield, Bhavik Shah, Patrick Kleyn, Ilia Ichetovkin, Ida Hatoum Moeller, William R. Mowrey, Lex H.T. Van der Ploeg   +7 more
doaj   +1 more source

Computational structure‐based drug design: Predicting target flexibility [PDF]

, 2018
The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early
Ding X., Dreher J., Khago D., Li Y., Samuel G.   +4 more
core   +2 more sources

Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor

Pharmaceuticals, 2021
Biologic drugs are large molecule pharmaceuticals that do not cross the blood–brain barrier (BBB), which is formed by the brain capillary endothelium.
William M. Pardridge
doaj   +1 more source

Morphogen Transport in Epithelia

, 2006
We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis
B. Houchmandzadeh, D. A. Lauffenburger, F. Jülicher, H. Meinhardt, K. Kruse, M. González-Gaitán, P. Pantazis, S. Morimura, T. Bollenbach   +8 more
core   +1 more source

Dimensionality of Motion and Binding Valency Govern Receptor–Ligand Kinetics As Revealed by Agent-Based Modeling

Frontiers in Immunology, 2017
Mathematical modeling and computer simulations have become an integral part of modern biological research. The strength of theoretical approaches is in the simplification of complex biological systems.
Teresa Lehnert, Teresa Lehnert, Marc Thilo Figge, Marc Thilo Figge, Marc Thilo Figge   +4 more
doaj   +1 more source