Results 181 to 190 of about 5,149,379 (301)

Neutralizing epitope mapping for deltacoronavirus receptor-binding domain and seroepidemiological survey across different animal species. [PDF]

Virulence
Li D, Hao L, Huang B, Wang Z, Wang Z, Guo M, Zhang Y, Deng J, Li Y, Zhao S, Tian K, Li X.   +11 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain. [PDF]

Commun Biol
Liccione MF, Scobey T, Froggatt HM, Pajon C, Yount BL, Yin Q, Spence TN, Walter EB, Saunders KO, Edwards RJ, Baric RS, Haynes BF, Cain DW, Sheahan TP, Wrapp D.   +14 more
europepmc   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Engineering Komagataella phaffii for secreted and surface-displayed production of SARS-CoV-2 receptor-binding domain and its immunogenicity evaluation. [PDF]

Microb Cell Fact
Dmytruk K, Dmytruk O, Semkiv M, Vasylyshyn R, Fayura L, Gaffke L, Podlacha M, Cyske Z, Pierzynowska K, Budylowski P, Ostrowski M, Wegrzyn G, Sibirny A.   +12 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Receptor binding domain-independent pancoronavirus vaccine design by fusion of conserved T/B Epitopes. [PDF]

Emerg Microbes Infect
Yang Y, Chen Y, Hong M, Zou R, Yao J, Li E, Wang J, Ye X, Xing Y, Tang Y, Lu X, Ding C, He H, Tong D, Shang Y, Wang J, Zhao G, Huang X, Feng F, Cheng Q, Li B, Huang B, Tan W, Chiu S, Jin T.   +24 more
europepmc   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice. [PDF]

Elife
Fan C, Cohen AA, Dam KA, Rorick AV, Priso Fils AI, Yang Z, Gnanapragasam PNP, Segovia LN, Huey-Tubman KE, Moon WJ, Lin PJC, Bjorkman PJ, Hoffmann MAG.   +12 more
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source