Results 1 to 10 of about 4,238,851 (307)
Quaternary Interaction of the HIV-1 Envelope Trimer with CD4 and Neutralizing Antibodies
Viruses, 2021 The entry of HIV-1 into host cells is initiated by the interaction of the viral envelope (Env) spike with the CD4 receptor. During this process, the spike undergoes a series of conformational changes that eventually lead to the exposure of the fusion ...
Qingbo Liu, Peng Zhang, Paolo Lusso
doaj +1 more source
Characterization and Function of Glycans on the Spike Proteins of SARS-CoV-2 Variants of Concern
Microbiology Spectrum, 2022 SARS-CoV-2 variants of concern (VOCs) pose a great challenge to viral prevention and treatment owing to spike (S) protein mutations, which enhance their infectivity and capacity for immune evasion.
Luping Zheng +5 more
doaj +1 more source
Pharmacology Research & Perspectives, 2023 Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity.
Edna J. Santos +11 more
doaj +1 more source
Receptor Binding Techniques [PDF]
Current Protocols in Neuroscience, 1997 Abstract This overview first discusses issues relating to the selection of radioligand for receptor binding assays, including the isotopic label and considerations pertaining to the pharmacological and chemical profile of the ligand.
Frey, Kirk A., Albin, Roger L.
openaire +3 more sources
Binding of glutamate to the umami receptor [PDF]
Biophysical Chemistry, 2010 The umami taste receptor is a heterodimer composed of two members of the T1R taste receptor family: T1R1 and T1R3. It detects glutamate in humans, and is a more general amino acid detector in other species. We have constructed homology models of the ligand binding domains of the human umami receptor (based on crystallographic structures of the ...
Cascales, J.J. López +3 more
openaire +5 more sources
EVOLUTION OF ANTIGEN BINDING RECEPTORS [PDF]
Annual Review of Immunology, 1999 ▪ Abstract This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity. Advances in molecular genetic technology now permit the study of immunoglobulin (Ig) and T cell receptor (TCR) genes in many species that are not commonly studied yet represent critical ...
Litman, Gary W. +2 more
openaire +3 more sources
Toxins, 2023 Receptor binding is a prerequisite process to exert the mosquitocidal activity of the Cry4Ba toxin of Bacillus thuringiensis subsp. israelensis.
Anon Thammasittirong +1 more
doaj +1 more source
Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness
Emerging Microbes and Infections, 2020 Influenza viruses have an error-prone polymerase complex that facilitates a mutagenic environment. Antigenic mutants swiftly arise from this environment with the capacity to persist in both humans and economically important livestock even in the face of ...
Joshua E. Sealy +6 more
doaj +1 more source
Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus
Protein & Cell, 2015 Influenza C virus, a member of the Orthomyxoviridae family, causes flu-like disease but typically only with mild symptoms. Humans are the main reservoir of the virus, but it also infects pigs and dogs.
Mingyang Wang, Michael Veit
doaj +1 more source
Dopamine systems adaptation during acquisition and consolidation of a skill
Frontiers in Integrative Neuroscience, 2014 The striatum plays a key role in motor learning. Striatal function depends strongly on dopaminergic neurotransmission, but little is known about neuroadaptions of the dopamine system during striatal learning.
Wolfgang H Sommer +3 more
doaj +1 more source