Results 1 to 10 of about 3,259,253 (212)

Synthesis of Sulochrin-125I and Its Binding Affinity as α-Glucosidase Inhibitor using Radioligand Binding Assay (RBA) Method [PDF]

Atom Indonesia, 2014
Most of diabetics patients have type 2 diabetes mellitus or non insulin dependent diabetes mellitus. Treatment type 2 diabetes mellitus can be done by inhibiting α-glucosidase enzyme which converts carbohydrates into glucose.
W. Lestari, V.Y. Susilo, S. Setiyowati, Triningsih, A. Ariyanto, P. Widayati, L.B.S. Kardono, A. Yanuar3   +7 more
doaj   +6 more sources

Detection by Radioligand Assay of Antibodies against Borna Disease Virus in Patients with Various Psychiatric Disorders

Clinical Diagnostic Laboratory Immunology, 2005
Using a radioligand assay, which preserves the natural form of the antigen, antibodies against Borna disease virus nucleoprotein and phosphoprotein were detected in 11 and 19 sera of 171 psychiatric patients, respectively.
H. Matsunaga, Susumu Tanaka, F. Sasao, Y. Nishino, M. Takeda, K. Tomonaga, K. Ikuta, N. Amino   +7 more
semanticscholar   +1 more source

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

Cells, 2022
The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission.
Ciara Frances Pugh, Brian Thomas DeVree, Solveig Gaarde Schmidt, Claus Juul Loland   +3 more
doaj   +1 more source

Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists

Journal of Pharmacological Sciences, 2010
The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Masaji Ishiguro, Takashi Nakamura, Takafumi Nagatomo   +4 more
doaj   +1 more source

Expression of Luteinizing Hormone-Releasing Hormone (LHRH) and Type-I LHRH Receptor in Transitional Cell Carcinoma Type of Human Bladder Cancer

Molecules, 2021
Bladder cancer (BC) is the tenth most frequently detected cancer in both sexes. Type-I luteinizing hormone-releasing hormone (LHRH) receptor (LHRH-R-I) is expressed not only in the pituitary, but also in several types of cancer disease.
Zsuzsanna Szabó, Balázs Dezső, Klára Fodor, Krisztián Szegedi, Tibor Flaskó, Erzsébet Szabó, Gábor Oláh, Éva Sipos, Nikoletta Dobos, János Gardi, Andrew V. Schally, Gábor Halmos   +11 more
doaj   +1 more source

Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT2C Modulators

Molecules, 2017
A series of pyrimidine derivatives 4a–i were synthesized and evaluated for their binding affinities towards 5-HT2C receptors. With regard to designed molecules 4a–i, the influence of the size of alkyl ether and the absolute configuration of a stereogenic
Juhyeon Kim, Hanbyeol Jo, Hyunseung Lee, Hyunah Choo, Hak Joong Kim, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min   +7 more
doaj   +1 more source

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

Toxins, 2015
The 5-HT3 receptor is a ligand-gated ion channel, which is expressed in the nervous system. Its antagonists are used clinically for treatment of postoperative- and radiotherapy-induced emesis and irritable bowel syndrome.
Reka A. Otvos, Janaki Krishnamoorthy Iyer, René van Elk, Chris Ulens, Wilfried M. A. Niessen, Govert W. Somsen, R. Manjunatha Kini, August B. Smit, Jeroen Kool   +8 more
doaj   +1 more source

A reliable assay for beta-adrenoceptors in intact isolated human fat cells with a hydrophilic radioligand, [3H]CGP-12177.

Journal of Lipid Research, 1988
The beta-adrenergic receptors of isolated human fat cells were identified using a new hydrophilic beta-adrenergic radioligand (+/-)[3H]CGP-12177. The results were compared with those from [3H]dihydroalprenolol binding to fat cells and membranes.
D Lacasa, P Mauriège, M Lafontan, M Berlan, Y Giudicelli   +4 more
doaj   +1 more source

Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding

Molecules, 2020
Herein, we report on the synthesis and pharmacological evaluation of ten novel fluorinated cinnamylpiperazines as potential monoamine oxidase B (MAO-B) ligands. The designed derivatives consist of either cinnamyl or 2-fluorocinnamyl moieties connected to
Ivana I. Jevtić, Thu Hang Lai, Jelena Z. Penjišević, Sladjana Dukić-Stefanović, Deana B. Andrić, Peter Brust, Sladjana V. Kostić-Rajačić, Rodrigo Teodoro   +7 more
doaj   +1 more source

Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

Molecules, 2022
The muscarinic acetylcholine receptor family is a highly sought-after target in drug and molecular imaging discovery efforts aimed at neurological disorders.
Jonas Kilian, Marlon Millard, Marius Ozenil, Dominik Krause, Khadija Ghaderi, Wolfgang Holzer, Ernst Urban, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler   +11 more
doaj   +1 more source