Results 1 to 10 of about 822,055 (188)

Radioligand Assay-Based Detection of Antibodies against SARS-CoV-2 in Hospital Workers Treating Patients with Severe COVID-19 in Japan [PDF]

Viruses, 2021
This study aimed to clarify whether infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is prevalent among the staff of a hospital providing treatment to patients with severe coronavirus disease 2019 (COVID-19) using radioligand ...
Hidenori Matsunaga, Akiko Makino, Yasuhiro Kato, Teruaki Murakami, Yuta Yamaguchi, Atsushi Kumanogoh, Yuichiro Oba, Satoshi Fujimi, Tomoyuki Honda, Keizo Tomonaga   +9 more
doaj   +4 more sources

Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay [PDF]

Frontiers in Physiology, 2023
Amino acids have diverse and essential roles in many cellular functions such as in protein synthesis, metabolism and as precursors of different hormones.
Satish Kantipudi, Daniel Harder, Dimitrios Fotiadis   +2 more
doaj   +3 more sources

Preliminary Screening of South African Plants for Binding Affinity to the Serotonin Reuptake Transporter and Adenosine A₁/A_2A Receptors

Scientia Pharmaceutica, 2023
In South African traditional medicine, Gomphocarpus fruticosus (L.) W.T. Aiton, Hypoxis hemerocallidea Fisch. & C.A. Mey., and Leonotis leonurus. (L.) R.Br.
Andisiwe Mnqika, Adeyemi O. Aremu, H. D. Janse van Rensburg, Makhotso Lekhooa   +3 more
doaj   +1 more source

Reliability of the thyroid stimulating hormone receptor antibodies level determination in diagnosing and prognosing of immunogenic hyperthyroidism [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. Graves disease (GD) is defined as hyperthyroidism with diffuse goiter caused by immunogenic disturbances. Antibodies to the thyroid stimulating hormone (TSH) receptors of thyroid gland (TRAb) have crucial pathogenetic importance in the ...
Aleksić Aleksandar Z., Aleksić Željka P., Mitov Vladimir M., Jović Miljan J.   +3 more
doaj   +1 more source

A High-Affinity ⁶⁴Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization

Pharmaceuticals, 2022
Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate.
Ji-Hun Park, Xuran Zhang, Hyunsoo Ha, Jung Young Kim, Joon Young Choi, Kyung-Han Lee, Youngjoo Byun, Yearn Seong Choe   +7 more
doaj   +1 more source

Comparative characterization of β-adrenoceptors in the bladder, heart, and lungs of rats: Alterations in spontaneously hypertensive rats

Journal of Pharmacological Sciences, 2022
The present study aimed to characterize and compare β-adrenoceptors in the rat bladder with those in the heart and lungs of SD rats (8–10 weeks old) using subtype-selective agonists and antagonists in a radioligand binding assay with (-)-[125I ...
Shizuo Yamada, Ryo Niiya, Yoshihiko Ito, Yoshihisa Kato, Satomi Onoue   +4 more
doaj   +1 more source

Novel 2-substituted-5-(4-chloro-2-phenoxy)phenyl-1,3,4-oxadiazole derivatives, ligands of GABAA/benzodiazepine receptor complex

EXCLI Journal : Experimental and Clinical Sciences, 2023
Agonists of Benzodiazepine (BZD) receptor are exhaustively used in the control of muscle spasms, seizure, anxiety, and insomnia. BZDs have some unwanted effects; therefore, the development of new BZD receptor agonists with better efficacy and fewer ...
Elham Rezaee, Fatemeh Ahmadi, Mahsa Shabaninia, Mona Khoramjouy, Zahra Azizi Farsani, Soraya Shahhosseini, Sayyed Abbas Tabatabai, Mehrdad Faizi   +7 more
doaj   +1 more source

[3H]-Spiperone Saturation Binding to Dopamine D2, D3 and D4 Receptors

Bio-Protocol, 2013
This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj   +1 more source

Machine Learning for Discovery of New ADORA Modulators

Frontiers in Pharmacology, 2022
Adenosine (ADO) is an extracellular signaling molecule generated locally under conditions that produce ischemia, hypoxia, or inflammation. It is involved in modulating a range of physiological functions throughout the brain and periphery through the ...
Ana C. Puhl, Zhan-Guo Gao, Kenneth A. Jacobson, Sean Ekins   +3 more
doaj   +1 more source

Quantifying Receptor Properties: the Tissue Segment Binding Method – a Powerful Tool for the Pharmacome Analysis of Native Receptors

Journal of Pharmacological Sciences, 2005
The radioligand binding assay technique is an extremely powerful tool for studying receptors. It allows an analysis of the interactions of hormones, neurotransmitters, and related drugs with their receptors.
Ikunobu Muramatsu, Takashi Tanaka, Fumiko Suzuki, Zhang Li, Yasuko Hiraizumi-Hiraoka, Abu Syed Md Anisuzzaman, Hatsumi Yamamoto, Takahiro Horinouchi, Shigeru Morishima   +8 more
doaj   +1 more source