Results 41 to 50 of about 822,055 (188)

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

Toxins, 2015
The 5-HT3 receptor is a ligand-gated ion channel, which is expressed in the nervous system. Its antagonists are used clinically for treatment of postoperative- and radiotherapy-induced emesis and irritable bowel syndrome.
Reka A. Otvos, Janaki Krishnamoorthy Iyer, René van Elk, Chris Ulens, Wilfried M. A. Niessen, Govert W. Somsen, R. Manjunatha Kini, August B. Smit, Jeroen Kool   +8 more
doaj   +1 more source

Synthesis, Biological Evaluation, and Docking Studies of Antagonistic Hydroxylated Arecaidine Esters Targeting mAChRs

Molecules, 2022
The muscarinic acetylcholine receptor family is a highly sought-after target in drug and molecular imaging discovery efforts aimed at neurological disorders.
Jonas Kilian, Marlon Millard, Marius Ozenil, Dominik Krause, Khadija Ghaderi, Wolfgang Holzer, Ernst Urban, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler   +11 more
doaj   +1 more source

songuno1/single-molecule-assay: Single-molecule assay analysis

, 2023
Single-molecule assay analysis tool for "Transcriptional pause extension benefits the stand-by rather than catch-up Rho-dependent termination"
Eunho Song
core   +1 more source

Stochastic modeling for the COMET-assay [PDF]

, 2003
We present a stochastic model for single cell gel electrophoresis (COMET-assay) data. Essential is the use of point process structures, renewal theory and reduction to intensity histograms for further data ...
Hösel, V., Boulesteix, Anne-Laure, Hösel, Volker, Liebscher, Volkmar, Liebscher, V.   +4 more
core   +1 more source

A reliable assay for beta-adrenoceptors in intact isolated human fat cells with a hydrophilic radioligand, [3H]CGP-12177.

Journal of Lipid Research, 1988
The beta-adrenergic receptors of isolated human fat cells were identified using a new hydrophilic beta-adrenergic radioligand (+/-)[3H]CGP-12177. The results were compared with those from [3H]dihydroalprenolol binding to fat cells and membranes.
D Lacasa, P Mauriège, M Lafontan, M Berlan, Y Giudicelli   +4 more
doaj   +1 more source

Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding

Molecules, 2020
Herein, we report on the synthesis and pharmacological evaluation of ten novel fluorinated cinnamylpiperazines as potential monoamine oxidase B (MAO-B) ligands. The designed derivatives consist of either cinnamyl or 2-fluorocinnamyl moieties connected to
Ivana I. Jevtić, Thu Hang Lai, Jelena Z. Penjišević, Sladjana Dukić-Stefanović, Deana B. Andrić, Peter Brust, Sladjana V. Kostić-Rajačić, Rodrigo Teodoro   +7 more
doaj   +1 more source

SPECT/CT Imaging, Biodistribution and Radiation Dosimetry of a 177Lu-DOTA-Integrin αvβ6 Cystine Knot Peptide in a Pancreatic Cancer Xenograft Model

Frontiers in Oncology, 2021
IntroductionPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant neoplasms, as many cases go undetected until they reach an advanced stage. Integrin αvβ6 is a cell surface receptor overexpressed in PDAC.
Sachindra Sachindra, Teresa Hellberg, Samantha Exner, Sonal Prasad, Sonal Prasad, Nicola Beindorff, Stephan Rogalla, Richard Kimura, Sanjiv Sam Gambhir, Bertram Wiedenmann, Carsten Grötzinger, Carsten Grötzinger, Carsten Grötzinger, Carsten Grötzinger   +13 more
doaj   +1 more source

Partial characterization of thyroid stimulating hormone in thyroid tumors using radioligand binding assay techniques [PDF]

Thyroid Stimulating Hormone (TSH) plays a crucial role in regulating thyroid function and is implicated in various thyroid disorders, including tumors.
Hassan, A. N. M. A.
core   +2 more sources

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors

Molecules, 2020
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik, Piotr F. J. Lipiński, Joanna Matalińska, Przemysław Koźmiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
doaj   +1 more source

Synthesis, stability, and cellular uptake of 131I-estradiol against MCF7 and T-47D human cell lines as a radioligand for binding assay

Heliyon, 2021
Estradiol is a steroid hormone that works as an agonist estrogen receptor (ER). This compound is widely used as a ligand and bind specifically to the ERα.
Isti Daruwati, Abednego Kristande Gwiharto, Ahmad Kurniawan, Isa Mahendra, Tri Hanggono Achmad, Mukh Syaifudin, Muchtaridi Muchtaridi   +6 more
doaj   +1 more source