Results 51 to 60 of about 822,055 (188)

ω-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Cav2.2 Ion Channels

Marine Drugs, 2012
The neuronal voltage-gated N-type calcium channel (Cav2.2) is a validated target for the treatment of neuropathic pain. A small library of anthranilamide-derived ω-Conotoxin GVIA mimetics bearing the diphenylmethylpiperazine moiety were prepared and ...
Peter J. Duggan, Aijun Yang, Irina Vetter, Jeffrey R. McArthur, Richard J. Lewis, Kellie L. Tuck, Jonathan B. Baell, Charlotte Elisabet Tranberg   +7 more
doaj   +1 more source

Discovery of benzothiazolylquinoline conjugates as novel human A3 receptor antagonists: biological evaluations and molecular docking studies [PDF]

Royal Society Open Science, 2018
Adenosine is known as an endogenous purine nucleoside and it modulates a wide variety of physiological responses by interacting with adenosine receptors. Among the four adenosine receptor subtypes, the A3 receptor is of major interest in this study as it
Bidisha Sarkar, Santanu Maiti, Gajanan Raosaheb Jadhav, Priyankar Paira   +3 more
doaj   +1 more source

Evaluation of the first automated thyroglobulin assay [PDF]

, 1999
The aim of this study was to investigate technical and analytical performance of the first automated thyroglobulin (Tg) assay (DPC-Immulite(R); Diagnostic Products Corporation, Los Angeles, USA).
Jacob, Karl, Seidel, Dietrich, Vogeser, Michael, Knesewitsch, Peter   +3 more
core   +1 more source

A Radioligand Binding Assay for Antitubulin Activity in Tumor Cells [PDF]

SLAS Discovery, 2006
The benzamide RH-5854 is shown to be highly potent toward tumor cells and to arrest nuclear division by a highly specific covalent binding to the beta-subunit of tubulin in the colchicine binding region. Binding of 3H-RH-5854 to beta-tubulin in HCT-116 colon cancer cells is saturable and has been exploited in the development of a cell-based competitive
David H, Young, Fernando M, Rubio, Paul O, Danis   +2 more
openaire   +2 more sources

Loop B is a major structural component of the 5-HT3 receptor [PDF]

, 2008
The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence of six peptide loops (A-F).
Thompson, Andrew J., Thompson, A.J., M. Lochner, Lummis, S. C. R., Lummis, S.C.R., S. C. R. Lummis, Lochner, M., A. J. Thompson, Lochner, Martin, Thompson, Andrew James   +9 more
core   +2 more sources

Miniaturized Bioaffinity Assessment Coupled to Mass Spectrometry for Guided Purification of Bioactives from Toad and Cone Snail

Biology, 2014
A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR ...
Ferry Heus, Reka A. Otvos, Ruud L. E. G. Aspers, Rene van Elk, Jenny I. Halff, Andreas W. Ehlers, Sébastien Dutertre, Richard J. Lewis, Sybren Wijmenga, August B. Smit, Wilfried M. A. Niessen, Jeroen Kool   +11 more
doaj   +1 more source

Dopamine D2-like receptors on human peripheral blood lymphocytes: a radioligand binding assay and immunocytochemical study

, 1999
1. Peripheral blood lymphocytes express dopamine D1-like and D2-like receptors which were investigated using radioligand binding assay and molecular biology techniques.
AMENTA, Francesco, E. BRONZETTI, L. FELICI, A. RICCI, TAYEBATI, Seyed Khosrow   +4 more
core  

A Comparative Study on Inter and Intra-Laboratory Reproducibility of Renin Measurement with a Conventional Enzymatic Method and a New Chemiluminescent Assay of Immunoreactive Renin

, 2009
Background: The activity of the renin-angiotensin system is usually evaluated as plasma renin activity (PRA, ng AI/ml/h) but the interlaboratory reproducibility of this enzymatic assay is notoriously scarce.
A. Morganti, on behalf of the European Group for the Validation of the DiaSorin Liaison Direct Renin Assay   +1 more
core   +2 more sources

Selection-Assay

, 2023
An in vitro selection assay was devlepoved to design small gRNAs that  can promote efficient A to I conversion using human ADAR2. This repository contains raw fastqc data for each round of the selection  assay, as well as the script used to analyse the ...
Juan Diaz (14557940)
core   +1 more source

Analyzing Radioligand Binding Data [PDF]

, 2000
A radioligand is a radioactively labeled drug that can associate with a receptor, transporter, enzyme, or any protein of interest. Measuring the rate and extent of binding provides information on the number of binding sites, and their affinity and ...
Neubig, Richard, Richard Neubig, Harvey Motulsky, Motulsky, Harvey   +3 more
core   +1 more source