Results 61 to 70 of about 822,055 (188)

Structure-Based Identification of Potent Natural Product Chemotypes as Cannabinoid Receptor 1 Inverse Agonists

Molecules, 2018
Natural products are an abundant source of potential drugs, and their diversity makes them a rich and viable prospective source of bioactive cannabinoid ligands.
Pankaj Pandey, Kuldeep K. Roy, Haining Liu, Guoyi Ma, Sara Pettaway, Walid F. Alsharif, Rama S. Gadepalli, John M. Rimoldi, Christopher R. McCurdy, Stephen J. Cutler, Robert J. Doerksen   +10 more
doaj   +1 more source

The measurement of testosterone and oestradiol-17[beta] using iodinated tracers and incorporating an affinity chromatography extraction procedure [PDF]

, 1985
The development of sensitive radioimmunoassays (RIA) for testosterone and oestradiol-17[beta], utilising 125I-radioligands, is described. Use of an homologous bridge at the same site of attachment, for both the radioligand and the steroid-carrier protein
Baxter, G., McBride, D., Shaw, M. P. K., Webb, R., Nordblom, Gerald D.   +4 more
core   +1 more source

Radioligand Binding to Nanodisc-Reconstituted Membrane Transporters Assessed by the Scintillation Proximity Assay

, 2016
The scintillation proximity assay is a powerful technique for measuring radioligand binding to membrane transporters and has become an integral part of high-throughput drug discovery screening efforts. Here we adapt the method for use with purified LeuT,
Mahmoud L. Nasr (1842112), Satinder K. Singh (1332018)   +1 more
core   +1 more source

A Robust Assay for Dexamethasone in Plasma Using a Heterologous 125I Radioligand and a Magnetizable Solid-Phase Antiserum

, 1990
An assay using an antiserum raised against a dexamethasone 21-hemisuccinate conjugate and the heterologous radioligand dexamethasone 21-(carboxymethyl) ether was developed, validated, and used to study the pharmacokinetics of this steroid for 12 h ...
Cook, Nigel N.J., Read, Graham G.F., Lejeune-Lenain, C., Riad-Fahmy, Diana   +3 more
core   +1 more source

On the kinetic features of orexin receptor antagonists at orexin receptors, transduction systems and receptor binding

Medicine in Drug Discovery
Orexin receptor antagonists are on the market or under development for the treatment of insomnia and a number of other neuropsychiatric disorders. Currently, suvorexant, lemborexant and daridorexant, three dual orexin receptor antagonists (DORAs) have ...
Daniel Hoyer, Laura H. Jacobson
doaj   +1 more source

Comparative Study of Carborane- and Phenyl-Modified Adenosine Derivatives as Ligands for the A2A and A3 Adenosine Receptors Based on a Rigid in Silico Docking and Radioligand Replacement Assay

Molecules, 2018
Adenosine receptors are involved in many physiological processes and pathological conditions and are therefore attractive therapeutic targets. To identify new types of effective ligands for these receptors, a library of adenosine derivatives bearing a ...
Marian Vincenzi, Katarzyna Bednarska, Zbigniew J. Leśnikowski   +2 more
doaj   +1 more source

Correction to Radioligand Binding to Nanodisc-Reconstituted Membrane Transporters Assessed by the Scintillation Proximity Assay

, 2016
Correction to Radioligand Binding to Nanodisc-Reconstituted Membrane Transporters Assessed by the Scintillation Proximity ...
Mahmoud L. Nasr (1842112), Satinder K. Singh (1332018)   +1 more
core   +1 more source

Assessment of antithyroglobulin and antimicrosomal autoantibodies in patients with autoimmune thyroid disease: comparison of haemagglutination assay, enzyme-linked immunoassay and radioligand assay.

, 1989
Four different assay systems for detection of antithyroglobulin (T-Ab) and thyroid antimicrosomal autoantibodies (M-Ab) were evaluated: two passive haemagglutination assays (PHA), an enzyme-linked immunoassay (ELISA) and a radioligand assay (RLA ...
Engler H, Ryff-deLèche A, Althaus B, Gerber H, Staub JJ   +4 more
core   +1 more source

Establishing a Receptor Binding Assay for Ciguatoxins: Challenges, Assay Performance and Application

Toxins
Ciguatera, a global issue, lacks adequate capacity for ciguatoxin analysis in most affected countries. The Caribbean region, known for its endemic ciguatera and being home to a majority of the global small island developing states, particularly needs ...
Lisbet Díaz-Asencio, Donaida Chamero-Lago, Gabriel L. Rojas-Abrahantes, Carlos M. Alonso-Hernández, Marie-Yasmine Dechraoui Bottein   +4 more
doaj   +1 more source

Genotoxicity testing of surface drinking water from three reservoirs in Sardinia (Italy) subjected to chlorination/chloramination

, 2017
INTRODUCTION: Sardinia (Italy) is the second-largest island in the Mediterranean Sea, with an area of 24,100 square kilometres. Surface waters collected and regulated in water reservoirs are the main water supplies in this Italian Region. Drinking water
Gianfredi Vincenza, Moretti Massimo, Posadino S, Vannini Samuele, Fatigoni C, Azara Antonio, Villarini Milena, Monarca Silvano   +7 more
core   +1 more source