Results 31 to 40 of about 822,055 (188)

Oxytocin receptor binding sites in the periphery of the neonatal mouse. [PDF]

PLoS ONE, 2017
Oxytocin (OXT) is a pleiotropic regulator of physiology and behavior. An emerging body of evidence demonstrates a role for OXT in the transition to postnatal life of the infant. To identify potential sites of OXT action via the OXT receptor (OXTR) in the
Maria A Greenwood, Elizabeth A D Hammock
doaj   +1 more source

Quantitation of the Folate Binding Protein in Human Cerebrospinal Fluid by an Enzyme-linked Immunosorbent Assay (ELISA)

Pteridines, 1989
An enzyme-linked immunosorbent assay (ELISA) was calibrated and used for quantitation of the folate binding protein in human cerebrospinal fluid. The precision of the assay in terms of the coefficient of variation was 6.3% intra-assay (10 replicate ...
Ingemann Hansen Steen, Holm Jan, Høier-Madsen Mimi   +2 more
doaj   +1 more source

Diagnostic value of combined islet antigen‐reactive T cells and autoantibodies assays for type 1 diabetes mellitus

Journal of Diabetes Investigation, 2021
Aims/Introduction Type 1 diabetes mellitus is a T cell‐mediated autoimmune disease. However, the determination of the autoimmune status of type 1 diabetes mellitus relies on islet autoantibodies (Abs), as T‐cell assay is not routinely carried out.
Wei Tang, Huiying Liang, Ying Cheng, Jiao Yuan, Gan Huang, Zhiguang Zhou, Lin Yang   +6 more
doaj   +1 more source

Summary of radioligand receptor binding assay components and reactions according to each receptor.

, 2015
Summary of radioligand receptor binding assay components and reactions according to each receptor.
Sek Peng Chin (737715), Lik Voon Kiew (534007), Lip Yong Chung (378399), Sri Devi Sukumaran (737716), Michael James Christopher Buckle (737717), Seetha Ramasamy (737714)   +5 more
core   +1 more source

Quantification of the Surface Expression of G Protein-coupled Receptors Using Intact Live-cell Radioligand Binding Assays

Bio-Protocol, 2020
G protein-coupled receptors (GPCRs) are the most structurally diverse family of signaling proteins and regulate a variety of cell function. For most GPCRs, the cell surface is their functional destination where they are able to respond a wide range of ...
Xin Xu, Guangyu Wu
doaj   +1 more source

Radioligand binding methods: practical guide and tips

, 1993
Radioligand binding assays are a relatively simple but extremely powerful tool for studying receptors. They allow an analysis of the interactions of hormones, neurotransmitters, growth factors, and related drugs with the receptors, studies of receptor ...
D. B. Bylund, M. L. Toews
core   +1 more source

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster

Cells, 2022
The dopamine transporter (DAT) is a member of the neurotransmitter:sodium symporter (NSS) family, mediating the sodium-driven reuptake of dopamine from the extracellular space thereby terminating dopaminergic neurotransmission.
Ciara Frances Pugh, Brian Thomas DeVree, Solveig Gaarde Schmidt, Claus Juul Loland   +3 more
doaj   +1 more source

Expression of Luteinizing Hormone-Releasing Hormone (LHRH) and Type-I LHRH Receptor in Transitional Cell Carcinoma Type of Human Bladder Cancer

Molecules, 2021
Bladder cancer (BC) is the tenth most frequently detected cancer in both sexes. Type-I luteinizing hormone-releasing hormone (LHRH) receptor (LHRH-R-I) is expressed not only in the pituitary, but also in several types of cancer disease.
Zsuzsanna Szabó, Balázs Dezső, Klára Fodor, Krisztián Szegedi, Tibor Flaskó, Erzsébet Szabó, Gábor Oláh, Éva Sipos, Nikoletta Dobos, János Gardi, Andrew V. Schally, Gábor Halmos   +11 more
doaj   +1 more source

Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists

Journal of Pharmacological Sciences, 2010
The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Masaji Ishiguro, Takashi Nakamura, Takafumi Nagatomo   +4 more
doaj   +1 more source

Identification of Optically Active Pyrimidine Derivatives as Selective 5-HT2C Modulators

Molecules, 2017
A series of pyrimidine derivatives 4a–i were synthesized and evaluated for their binding affinities towards 5-HT2C receptors. With regard to designed molecules 4a–i, the influence of the size of alkyl ether and the absolute configuration of a stereogenic
Juhyeon Kim, Hanbyeol Jo, Hyunseung Lee, Hyunah Choo, Hak Joong Kim, Ae Nim Pae, Yong Seo Cho, Sun-Joon Min   +7 more
doaj   +1 more source