Results 21 to 30 of about 822,055 (188)
Microbial Cell Factories, 2022 Background Replacement of radioligand binding assays with antibody-antigen interaction-based approaches for quantitative analysis of G protein-coupled receptor (GPCR) levels requires the use of purified protein standards containing the antigen.
Miquel Saumell-Esnaola +10 more
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Validation of a [3H]Astemizole Binding Assay in HEK293 Cells Expressing HERG K+ Channels
Journal of Pharmacological Sciences, 2004 A radioligand binding assay for the HERG (human ether-a-go-go-related gene) K+ channel was developed to identify compounds which may have inhibitory activity and potential cardiotoxicity.
Peter J.S. Chiu +8 more
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Functional Authentication of a Novel Gastropod Gonadotropin-Releasing Hormone Receptor Reveals Unusual Features and Evolutionary Insight. [PDF]
PLoS ONE, 2016 A gonadotropin-releasing hormone (GnRH)-like molecule was previously identified in a gastropod, Aplysia californica, and named ap-GnRH. In this study, we cloned the full-length cDNA of a putative ap-GnRH receptor (ap-GnRHR) and functionally authenticated
Scott I Kavanaugh, Pei-San Tsai
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A radioligand binding assay for the insulin-like growth factor 2 receptor.
PLoS ONE, 2020 Insulin-like growth factors 2 and 1 (IGF2 and IGF1) and insulin are closely related hormones that are responsible for the regulation of metabolic homeostasis, development and growth of the organism.
Pavlo Potalitsyn +7 more
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Cells, 2022 Chemokine receptors are extensively involved in a broad range of physiological and pathological processes, making them attractive drug targets. However, despite considerable efforts, there are very few approved drugs targeting this class of seven ...
Stefanie Alexandra Eberle +1 more
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Artificial tissue binding models : development and comparative evaluation of high - throughput lipophilicity assays and their use for PET tracer optimization [PDF]
, 2015 The purpose of this thesis was to increase the efficiency of the Positron Emission Tomography (PET) tracer development process. Since many neuroimaging agents fail due to undesirably high non-specific binding (NSB) to brain tissue, we aimed at estimating
Assmus, Frauke
core +1 more source
Journal of Pharmacological Sciences, 2016 The present study aimed to directly characterize specific binding sites of tritium ([3H])-labeled imidafenacin, a new radioligand for labeling muscarinic receptors, in the bladder and other peripheral or central nervous tissues of rats.
Shiori Kuraoka +5 more
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PLoS Computational Biology, 2021 Adenosine receptors (ARs) have been demonstrated to be potential therapeutic targets against Parkinson's disease (PD). In the present study, we describe a multistage virtual screening approach that identifies dual adenosine A1 and A2A receptor ...
Mukuo Wang +4 more
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RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS
, 1987 A NEW RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS IS DESCRIBED IN THIS STUDY. THE MAIN ASSAY REAGENTS ARE: A MIXTURE OF NB-(4-OH-3-125I-PHENYL)ETHYL] AND N-[B-(4-OH-3,5-DI- 125I-PHENYL)ETHYL] BIOTINAMIDES (RADIOTRACER),AVIDIN (BINDING ...
Λιβανίου, Ευαγγελία +1 more
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DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND
Zagazig Journal of Pharmaceutical Sciences, 1993 Serotonin (5-HT) 1A receptors have been shown to have physiological, biochemical pharmacological and clinical values. The piperazino derivative 1 was rationally designed as a bulky, lipophilic N4-substituted arylpiperazine. Radioligand binding assay of 1
Mohamed El-Bermawy
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