Results 21 to 30 of about 3,259,253 (212)
Journal of Pharmacological Sciences, 2022 The present study aimed to characterize and compare β-adrenoceptors in the rat bladder with those in the heart and lungs of SD rats (8–10 weeks old) using subtype-selective agonists and antagonists in a radioligand binding assay with (-)-[125I ...
Shizuo Yamada +4 more
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Development of a Radioligand Binding Assay for Detection of Gastrin/CCKB Receptors in the Human Gastrointestinal Tract [PDF]
, 1996 The initial strategy of the thesis (Chapter 3) examined the presence and characterisation of gastrin/CCKB receptors in the rat pancreatic cell line, AR42J. This cell line was chosen due to its continuous expression of high affinity gastrin/CCKB receptors
Mackenzie, Janet Fraser
core +6 more sources
EXCLI Journal : Experimental and Clinical Sciences, 2023 Agonists of Benzodiazepine (BZD) receptor are exhaustively used in the control of muscle spasms, seizure, anxiety, and insomnia. BZDs have some unwanted effects; therefore, the development of new BZD receptor agonists with better efficacy and fewer ...
Elham Rezaee +7 more
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[3H]-Spiperone Saturation Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj +1 more source
Journal of Pharmacological Sciences, 2005 The radioligand binding assay technique is an extremely powerful tool for studying receptors. It allows an analysis of the interactions of hormones, neurotransmitters, and related drugs with their receptors.
Ikunobu Muramatsu +8 more
doaj +1 more source
Machine Learning for Discovery of New ADORA Modulators
Frontiers in Pharmacology, 2022 Adenosine (ADO) is an extracellular signaling molecule generated locally under conditions that produce ischemia, hypoxia, or inflammation. It is involved in modulating a range of physiological functions throughout the brain and periphery through the ...
Ana C. Puhl +3 more
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Nuclear Medicine and Biology, 2019 Introduction: Determination of the target-binding fraction (TBF) of radiopharmaceuticals using cell-based assays is prone to inconsistencies arising from several intrinsic and extrinsic factors. Here, we report a cell-free quantitative method of analysis
Sai Kiran Sharma +9 more
semanticscholar +1 more source
A partially automated radioligand binding assay system for use in clinical and pharmaceutical research [PDF]
, 1993 Using a Tecan robotic sample processor and IBM compatible PCs we have developed a flexible, partially automated radioligand binding assay system. It handles pipetting parameters of up to 16 saturation or competition experiments at a time with up to 24 ...
Liebl, B. +4 more
core +1 more source
Towards the Development of a Targeted Albumin-Binding Radioligand for Theranostic Applications: Synthesis, Radiolabelling and Preliminary In Vivo Studies [PDF]
, 2020 GluCAB is a newly synthesised macrocyclic radioligand designed to bind in vivo to albumin (HSA) for the purpose of development as a dual-targeting oncological theranostic agent.
Iqbal, Parker +5 more
core +2 more sources
[3H]-Spiperone Competition Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj +1 more source