Results 241 to 250 of about 734,847 (386)

Modeling Nanoparticle Internalization via Receptor-Mediated Endocytosis [PDF]

, 2014
Anand Banerjee, Alexander M. Berezhkovskii, Ralph Nossal   +2 more
openalex   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients

Proceedings of the National Academy of Sciences of the United States of America, 2013
C. Gorvin, M. Wilmer, S. Piret, B. Harding, L. P. Van den Heuvel, O. Wrong, P. Jat, J. Lippiat, E. Levtchenko, R. Thakker   +9 more
semanticscholar   +1 more source

Epidermal Growth Factor Receptor–Mediated Membrane Type 1 Matrix Metalloproteinase Endocytosis Regulates the Transition between Invasive versus Expansive Growth of Ovarian Carcinoma Cells in Three-Dimensional Collagen [PDF]

, 2009
Natalie M. Moss, Yueying Liu, Jeff Johnson, Philip Debiase, Jonathan Jones, Laurie G. Hudson, Hidayatullah G. Munshi, M. Sharon Stack   +7 more
openalex   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis [PDF]

, 2002
James W. Booth, Moo-Kyung Kim, Andrzej Jankowski, Alan D. Schreiber, Sergio Grinstein   +4 more
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

MICAL-like1 mediates epidermal growth factor receptor endocytosis

, 2011
Nancy Abou-Zeid, Rudy Pandjaitan, Lucie Sengmanivong, Violaine David, Gwenaelle Le Pavec, Jean Salamero, Ahmed Zahraoui   +6 more
openalex   +2 more sources

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Sequestration of the G protein βγ subunit complex inhibits receptor-mediated endocytosis

, 1998
Hsin Chieh Lin, Joseph A. Duncan, Tohru Kozasa, Alfred G. Gilman   +3 more
openalex   +2 more sources