Results 171 to 180 of about 3,511,004 (317)

GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts

, 2008
Dietmar Benke, Andrea Barberis, Sascha Kopp, Karl‐Heinz Altmann, Monika Schubiger, Kaspar E. Vogt, Uwe Rudolph, Hanns Möhler   +7 more
openalex   +1 more source

The tomato I gene for Fusarium wilt resistance encodes an atypical leucine‐rich repeat receptor‐like protein whose function is nevertheless dependent on SOBIR1 and SERK3/BAK1 [PDF]

, 2016
Ann‐Maree Catanzariti, Tran Thi Huong, Pierrick Bru, Mara de Sain, Louise F. Thatcher, Martijn Rep, David A. Jones   +6 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Rewiring gene circuits to dissect oscillatory signaling dynamics. [PDF]

Genes Dev
van Oostrom MJ, Sonnen KF.
europepmc   +1 more source

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis [PDF]

, 2012
Fang Zhao, Jennifer L. Cannons, Mala Dutta, Gillian M. Griffiths, Pamela L. Schwartzberg   +4 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters

JACS Au, 2021
Ming-Liang Han, Jun-Jie Chen, Hui Xu, Zhi-Cong Huang, Wei Huang, Yu-Wen Liu, Xing Wang, Min Liu, Zi-Qiong Guo, Hui-Xiong Dai   +9 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Characterization of the GTPγS release function of a G protein-coupled receptor. [PDF]

Nat Commun
Bohn LM, Stahl EL.
europepmc   +1 more source

Effect of WIN 55212-2, a Cannabinoid Receptor Agonist, on Aqueous Humor Dynamics in Monkeys [PDF]

, 2003
Fred Y. Chien
openalex   +1 more source