Results 301 to 310 of about 7,559,498 (434)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Modulation of plant growth and development through altered ethylene binding affinity of the ethylene receptor ETR1. [PDF]

BMC Plant Biol
Aman S, Swain S, Dutta E, Abbas S, Li N, Shakeel SN, Binder BM, Schaller GE.   +7 more
europepmc   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Wuzhuyu Decoction Relieves Chronic Migraine by Regulating 5-HT1A and 3A Receptors-Mediated CREB Signaling Pathway in Brain and Intestine. [PDF]

Pharmaceuticals (Basel)
Song Z, Li M, Zhou Z, Guo X, Wang Q, Zhang Z, Wang K, Zheng Q, Gou W, Wu S, Zhao H, Gong M.   +11 more
europepmc   +1 more source

PHOTOREGULATION OF BIOLOGICAL ACTIVITY BY PHOTOCHROMIC REAGENTS, III. PHOTOREGULATION OF BIOELECTRICITY BY ACETYLCHOLINE RECEPTOR INHIBITORS

, 1969
Walter J. Deal, Bernard F. Erlanger, David Nachmansohn   +2 more
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Artificial Intelligence: A New Tool for Structure-Based G Protein-Coupled Receptor Drug Discovery. [PDF]

Biomolecules
Chung J, Hahn H, Flores-Espinoza E, Thomsen ARB.   +3 more
europepmc   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source

Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility. [PDF]

Sci Rep
Ayan E.
europepmc   +1 more source

Similarities between active sites of acetylcholine receptor and acetylcholinesterase tested with quinolinium ions.

, 1966
Thomas R. Podleski, David Nachmansohn
openalex   +1 more source