Results 311 to 320 of about 7,559,498 (434)

IP3 receptors [PDF]

Current Biology, 2003
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Navigating TAM receptor dynamics in tumour immunotherapy. [PDF]

Cancer Immunol Immunother
Yang J, Chen G, Wang R, Song C, Yi H.
europepmc   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

Is muscarinic receptor agonist effective and tolerant for schizophrenia? [PDF]

BMC Psychiatry
Guo X, Deng R, Lai J, Hu S.
europepmc   +1 more source

Studies of Drug Receptors on the Plain Muscle. III

, 1961
Yukio Ishida
openalex   +2 more sources

Inhibition of death receptor signals by cellular FLIP

Nature, 1997
M. Irmler, M. Thome, M. Hahne, P. Schneider, K. Hofmann, Véronique Steiner, J. Bodmer, M. Schröter, K. Burns, C. Mattmann, D. Rimoldi, L. French, J. Tschopp   +12 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

A meta-analysis of the efficacy and safety of immunomodulators in the treatment of severe COVID-19. [PDF]

J Int Med Res
Ju X, Li J, Huang H, Qing Y, Sandeep B.
europepmc   +1 more source

The Structural Biology of T-Cell Antigen Detection at Close Contacts. [PDF]

Immunol Rev
Lui Y, Ferreira Fernandes J, Vuong MT, Sharma S, Santos AM, Davis SJ.   +5 more
europepmc   +1 more source