Results 11 to 20 of about 266,137 (295)

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). [PDF]

J Biol Chem, 2015
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulating blood glucose levels. Consequently, these receptors have been identified as targets for novel diabetes treatments. However, drugs acting at the GLP-1 receptor, although having clinical efficacy, have been associated with severe adverse side-effects ...
Weston C, Lu J, Li N, Barkan K, Richards GO, Roberts DJ, Skerry TM, Poyner D, Pardamwar M, Reynolds CA, Dowell SJ, Willars GB, Ladds G.   +12 more
europepmc   +8 more sources

Molecular interaction of an antagonistic amylin analog with the extracellular domain of receptor activity-modifying protein 2 assessed by fluorescence polarization. [PDF]

Biophys Chem, 2020
The peptide hormone amylin receptor is a complex of the calcitonin receptor (CTR) and an accessory protein called receptor activity-modifying proteins (RAMPs). The soluble extracellular domain (ECD) of CTR is an important binding site of peptide hormone calcitonin.
Lee S, Pioszak AA.
europepmc   +4 more sources

Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy. [PDF]

Hypertension, 2016
RAMPs (receptor activity–modifying proteins) serve as oligomeric modulators for numerous G-protein–coupled receptors, yet elucidating the physiological relevance of these interactions remains complex. Ramp2 null mice are embryonic lethal, with cardiovascular developmental defects similar to those observed in mice ...
Kechele DO, Dunworth WP, Trincot CE, Wetzel-Strong SE, Li M, Ma H, Liu J, Caron KM.   +7 more
europepmc   +4 more sources

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties [PDF]

Journal of Biological Chemistry, 2016
Adrenomedullin (AM) is a peptide hormone with numerous effects in the vascular systems. AM signals through the AM1 and AM2 receptors formed by the obligate heterodimerization of a G protein-coupled receptor, the calcitonin receptor-like receptor (CLR), and receptor activity-modifying proteins 2 and 3 (RAMP2 and RAMP3), respectively. These different CLR-
Harriet A. Watkins, Madhuri Chakravarthy, Rekhati S. Abhayawardana, Joseph J. Gingell, Michael Garelja, Meenakshi Pardamwar, James M.W.R. McElhinney, Alex Lathbridge, Arran Constantine, Paul W.R. Harris, Tsz-Ying Yuen, Margaret A. Brimble, James Barwell, David R. Poyner, Michael J. Woolley, Alex C. Conner, Augen A. Pioszak, Christopher A. Reynolds, Debbie L. Hay   +18 more
openaire   +4 more sources

Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity–Modifying Protein 2 [PDF]

Circulation Research, 2006
Adrenomedullin (AM) levels are elevated in cardiovascular disease, but little is known of the role of specific receptor components. AM acts via the calcitonin receptor-like receptor (CLR) interacting with a receptor-activity–modifying protein (RAMP). The AM 1 receptor is composed of CLR and RAMP2, and the calcitonin
Tam, C W, Husmann, K, Clark, N C, Clark, J E, Lazar, Z, Ittner, L M, Gotz, J, Douglas, G, Grant, A D, Sugden, D, Poston, L, Poston, R, McFadzean, I, Marber, M S, Fischer, J A, Born, W, Brain, S D   +16 more
openaire   +4 more sources

Osteoclast-like cells express receptor activity modifying protein 2: application of laser capture microdissection [PDF]

Journal of Molecular Endocrinology, 2005
Receptor activity modifying proteins (RAMPs) act as receptor modulators that determine the ligand specificity of receptors for the calcitonin (CT) family. The purpose of this study was to analyze the expression of RAMPs in osteoclast-like cells using the laser capture microdissection (LCM) technique.
M, Nakamura, S, Morimoto, Q, Yang, T, Hisamatsu, N, Hanai, Y, Nakamura, I, Mori, K, Kakudo   +7 more
openaire   +2 more sources

Intermedin attenuates LPS-induced inflammation in the rat testis. [PDF]

PLoS ONE, 2013
First reported as a vasoactive peptide in the cardiovascular system, intermedin (IMD), also known as adrenomedullin 2 (ADM2), is a hormone with multiple potent roles, including its antioxidant action on the pulmonary, central nervous, cardiovascular and ...
Lei Li, Ping Ma, Yongjun Liu, Chen Huang, Wai-sum O, Fai Tang, Jian V Zhang   +6 more
doaj   +1 more source

Adrenomedullin is an Important Pathological Mediator in Progression of Chronic Neuropathic Pain

Frontiers in Bioscience-Landmark, 2022
Background: The characterization of neuropathic pain is maladaptive plasticity within the nociceptive system. Multiple alterations contribute to complex pain phenotypes. Adrenomedullin (AM) has been documented to be a pain mediator.
Chunmei Wang, Yaping Xue, Qiuhua Lu, Yonghui Shi, Wei Tang, Dongmei Wang   +5 more
doaj   +1 more source

Coexpression of Calcitonin Receptor-Like Receptor and Receptor Activity-Modifying Protein 2 or 3 Mediates the Antimigratory Effect of Adrenomedullin [PDF]

Endocrinology, 2003
Three isoforms of the receptor activity-modifying protein (RAMP) are thought to transport the calcitonin receptor-like receptor (CRLR) to the plasma membrane to function as calcitonin gene-related peptide or adrenomedullin receptors, but their role remains largely unknown.
Nozomi, Fukai, Masayoshi, Shichiri, Naoko, Ozawa, Mika, Matsushita, Yukio, Hirata   +4 more
openaire   +2 more sources

Oocyte-specific disruption of adrenomedullin 2 gene enhances ovarian follicle growth after superovulation

Frontiers in Endocrinology, 2022
BackgroundAdrenomedullin 2 (ADM2), adrenomedullin (ADM), and calcitonin gene-related peptides (α- and β-CGRPs) signal through heterodimeric calcitonin receptor-like receptor/receptor activity-modifying protein 1, 2 and 3 (CLR/RAMP1, 2 and 3) complexes ...
Chia Lin Chang, Wei-Che Lo, Ta-Hsien Lee, Jia-Yi Sung, Yen Ju Sung   +4 more
doaj   +1 more source