Results 261 to 270 of about 266,137 (295)

Receptor activity modifying protein‐3 mediates the protumorigenic activity of lysyl oxidase‐like protein‐2

The FASEB Journal, 2010
Lysyl oxidase‐like protein‐2 (LOXL2) induces epithelial to mesenchymal transition and promotes invasiveness. To understand the mechanisms involved, we examined the effect of LOXL2 overexpression in MCF‐7 cells on gene expression.
Vera, Brekhman, Jennie, Lugassie, Shelly, Zaffryar-Eilot, Edmond, Sabo, Ofra, Kessler, Victoria, Smith, Hana, Golding, Gera, Neufeld   +7 more
openaire   +2 more sources

Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2

Biochemical and Biophysical Research Communications, 2010
Receptor activity-modifying protein 2 (RAMP2) enables calcitonin receptor-like receptor (CRLR) to form an adrenomedullin (AM)-specific receptor. Here we investigated the function of the cytoplasmic C-terminal tail (C-tail) of human (h)CRLR by co-transfecting its C-terminal mutants into HEK-293 cells stably expressing hRAMP2.
Kenji, Kuwasako, Kazuo, Kitamura, Sayaka, Nagata, Tomomi, Hikosaka, Johji, Kato   +4 more
openaire   +2 more sources

Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function

Molecular and Cellular Endocrinology, 2000
The calcitonin receptor-like receptor (CRLR) requires novel receptor-activity-modifying proteins (RAMPs) for its function as an adrenomedullin (ADM) or a calcitonin (CT) gene-related peptide (CGRP) receptor. Here, mouse cDNA clones representing expressed sequence tags (ESTs) in the GenEMBL database have been identified. They encode for proteins with 70,
K, Husmann, P M, Sexton, J A, Fischer, W, Born   +3 more
openaire   +2 more sources

Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2

Biochemical and Biophysical Research Communications, 2004
The calcitonin-like receptor (CLR) associated with receptor-activity-modifying proteins (RAMP) 1 or -2 recognizes calcitonin gene-related peptide (CGRP) and adrenomedullin (AM), respectively. The amino acid sequence CNRTWDGWLCW corresponding to residues 64-74 in the extracellular N-terminus of the CLR is conserved. The Asp(69) (D(69)) is present in all
Lars M, Ittner, Felix, Luessi, Daniela, Koller, Walter, Born, Jan A, Fischer, Roman, Muff   +5 more
openaire   +2 more sources

Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells

Peptides, 2001
Adrenomedullin is a potent vasodilator peptide originally isolated from a pheochromocytoma. Recently, a novel adrenomedullin receptor has been identified as a complex consisting of calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein (RAMP) 2.
T, Kitamuro, K, Takahashi, K, Totsune, M, Nakayama, O, Murakami, W, Hida, K, Shirato, S, Shibahara   +7 more
openaire   +2 more sources

Receptor Activity Modifying Protein 2 Distribution in the Rat Central Nervous System and Regulation by Changes in Blood Pressure

Journal of Neuroendocrinology, 2003
AbstractThe neuropeptide, adrenomedullin, acts in the central nervous system (CNS) to regulate blood pressure, at least partly through an adrenomedullin receptor which is composed of receptor activity modifying protein 2 (RAMP‐2) and calcitonin receptor‐like receptor (CRLR).
T J E, Stachniak, T L, Krukoff
openaire   +2 more sources

Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure

Clinical Science, 2000
Adrenomedullin is a vasodilator peptide produced in various organs, including heart and kidney. A novel adrenomedullin receptor complex has recently been identified, namely the calcitonin receptor-like receptor (CRLR) and receptor-activity modifying protein (RAMP) 2.
K, Totsune, K, Takahashi, H S, Mackenzie, O, Murakami, Z, Arihara, M, Sone, T, Mouri, B M, Brenner, S, Ito   +8 more
openaire   +2 more sources

Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia

Peptides, 2003
Adrenomedullin is a potent vasodilator peptide originally isolated from a pheochromocytoma. Recently, a novel adrenomedullin receptor has been identified as a complex of calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2).
Yong Fen, Qi, Yan Rong, Shi, Ding Fang, Bu, Yong Zheng, Pang, Chao Shu, Tang   +4 more
openaire   +2 more sources

Hypoxic Induction of Receptor Activity-Modifying Protein 2 Alters Regulation of Pulmonary Endothelin-1 by Adrenomedullin: Induction under Normoxia Versus Inhibition under Hypoxia

The Journal of Pharmacology and Experimental Therapeutics, 2007
The vasodilator adrenomedullin (AM) is up-regulated in pulmonary hypertension, and inhaled AM is beneficial in patients. Therefore, we investigated the effects of AM on pulmonary endothelin-1 (ET-1). In normoxic isolated rat lungs (IRL) and rat pulmonary artery endothelial cells (RPAEC), the calcitonin gene-related peptide type-1 receptor (CGRP1R ...
Thomas, Dschietzig, Christoph, Richter, Louay, Asswad, Gert, Baumann, Karl, Stangl   +4 more
openaire   +2 more sources

Determinants of 1-Piperidinecarboxamide, N-[2-[[5-Amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors—The Role of Receptor Activity Modifying Protein 1

Molecular Pharmacology, 2006
1-Piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS), a calcitonin gene-related peptide (CGRP) receptor antagonist, can alleviate the symptoms of migraine and is highly selective for CGRP over ...
Debbie L, Hay, George, Christopoulos, Arthur, Christopoulos, Patrick M, Sexton   +3 more
openaire   +2 more sources