Results 31 to 40 of about 266,137 (295)

Receptor activity modifying proteins (RAMPs) interact with theVPAC₂receptor andCRF₁receptors and modulate their function [PDF]

British Journal of Pharmacology, 2013
Background and PurposeAlthough it is established that the receptor activity modifying proteins (RAMPs) can interact with a number ofGPCRs, little is known about the consequences of these interactions. Here the interaction ofRAMPs with the glucagon‐like peptide 1 receptor (GLP‐1 receptor), the human vasoactive intestinal polypeptide/pituitaryAC ...
D, Wootten, H, Lindmark, M, Kadmiel, H, Willcockson, K M, Caron, J, Barwell, T, Drmota, D R, Poyner   +7 more
openaire   +3 more sources

Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age [PDF]

Journal of Biological Chemistry, 2007
RAMPs (receptor activity modifying proteins) impart remarkable effects on G protein-coupled receptor (GPCR) signaling. First identified through an interaction with the calcitonin receptor-like receptor (CLR), these single transmembrane proteins are now known to modulate the in vitro ligand binding affinity, trafficking, and second messenger pathways of
Ryan, Dackor, Kim, Fritz-Six, Oliver, Smithies, Kathleen, Caron   +3 more
openaire   +2 more sources

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources

Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells [PDF]

Journal of Endocrinology, 2006
Adrenomedullin (AM) is a multifunctional peptide hormone, which plays a significant role in vasodilation and angiogenesis, implicating it in hypertension as well as in carcinogenesis. AM exerts its effects via the calcitonin receptor-like receptor (CRLR, now known as CL) complexed with either receptor activity modifying protein (RAMP) 2 or 3.
Nele, Schwarz, Derek, Renshaw, Supriya, Kapas, Joy P, Hinson   +3 more
openaire   +2 more sources

An unexpected role for the conserved ADAM-family metalloprotease ADM-2 in Caenorhabditis elegans molting.

PLoS Genetics, 2022
Molting is a widespread developmental process in which the external extracellular matrix (ECM), the cuticle, is remodeled to allow for organismal growth and environmental adaptation.
Braveen B Joseph, Phillip T Edeen, Sarina Meadows, Shaonil Binti, David S Fay   +4 more
doaj   +1 more source

Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability [PDF]

, 2018
Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle ...
Barrantes, Francisco Jose, Camino, Pablo A., Mosqueira, Alejo   +2 more
core   +2 more sources

RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models

EMBO Molecular Medicine, 2018
Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early‐onset DYT1 dystonia.
Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Evelyne Doudnikoff, Venetia Zachariou, Rose E Goodchild, Nicola B Mercuri, Marcello D'Amelio, Massimo Pasqualetti, Erwan Bezard, Antonio Pisani   +16 more
doaj   +1 more source

Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells.

PLoS ONE, 2023
Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) and ...
Elena C Sigmund, Aline Bauer, Barbara D Jakobs, Hazal Tatliadim, Carlotta Tacconi, Marcus Thelen, Daniel F Legler, Cornelia Halin   +7 more
doaj   +1 more source

Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile [PDF]

, 2013
<p>Background: Cardiovascular disorders, including coronary artery bypass graft failure and in-stent restenosis remain significant opportunities for the advancement of novel therapeutics that target neointimal hyperplasia, a characteristic of both ...
AA Soyombo, AC Bradshaw, AC Bradshaw, AF Merrick, AH Baker, AL Parker, AL Parker, Alan L Parker, Andrew H Baker, Angela C Bradshaw, Audrey F Wright, B Vigl, C-C Liang, Christian Delles, DM Roberts, F Sakurai, F Vigant, K Doronin, Katie M White, KD Newman, M Hedman, M Hedman, M Jessup, MC Sprangers, MD Rekhter, MJE Havenga, MM Zanone, MO Hilutnen, N Inoue, O Kalyuzhniy, P Lemarchand, R Alba, R Alba, R Vogels, Raul Alba, RD Lopes, Robert A McDonald, RR Bradley, S Ishii, S Kuriyama, SA Nicklin, SD Carson, SJ George, SJ George, SM Sumida, SN Waddington, TD Henry, TW Johnson   +47 more
core   +2 more sources

The role of ubiquitination and hepatocyte growth factor-regulated tyrosine kinase substrate in the degradation of the adrenomedullin type I receptor [PDF]

, 2017
Calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 2 (RAMP2) comprise a receptor for adrenomedullin (AM). Although it is known that AM induces internalization of CLR•RAMP2, little is known about the molecular mechanisms ...
A Gullapalli, A Hershko, A Marchese, A Marchese, AC Hanyaloglu, AC Hocke, B Goulet, B Hasdemir, B Hasdemir, B Sehat, B Temmesfeld-Wollbruck, BE Padilla, BL Wolfe, EF Grady, EW Ades, GS Cottrell, IL Goldknopf, J Trejo, JM Bomberger, JN Hislop, JN Hislop, JN Hislop, K Chaturvedi, K Haglund, K Kitamura, K Kuwasako, K Kuwasako, K Shtiegman, KE Longva, KG Bache, KM Caron, L Guery, L Hicke, LM McLatchie, M Christ-Crain, M Christ-Crain, M Komada, M Tanowitz, MR Dores, MR Dores, N Sirisaengtaksin, RH Moore, RM Gage, RT Dackor, S Hippenstiel, S Urbe, SD Brain, SK Shenoy, T Koyama, TA Czyzyk, WP Dunworth, Z Xia   +51 more
core   +2 more sources