Results 181 to 190 of about 396,884 (345)

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.

Proceedings of the National Academy of Sciences of the United States of America, 1994
S. Corey, A. Burkhardt, J. Bolen, R. Geahlen, L. Tkatch, D. Tweardy   +5 more
semanticscholar   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer. [PDF]

Curr Issues Mol Biol
Alrumaihi F, Rahmani AH, Prabhu SV, Kumar V, Anwar S.   +4 more
europepmc   +1 more source

Signaling Complexes and Protein-Protein Interactions Involved in the Activation of the Ras and Phosphatidylinositol 3-Kinase Pathways by the c-Ret Receptor Tyrosine Kinase [PDF]

, 2000
Valérie Besset, Rizaldy P. Scott, Carlos F. Ibáñez   +2 more
openalex   +1 more source

Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice

Advanced Science, EarlyView.
An AI‐powered system decodes emotional valence from mouse facial expressions, identifying ear dynamics as key indicators. By integrating facial kinematics with synchronized neural recordings, this approach establishes a direct link between behavior and brain activity, advancing automated emotion recognition in animal models.
Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao   +9 more
wiley   +1 more source

The Role of Protein Kinases in the Suppressive Phenotype of Myeloid-Derived Suppressor Cells. [PDF]

Int J Mol Sci
Kali A, Abdolla N, Perfilyeva YV, Ostapchuk YO, Tleulieva R.   +4 more
europepmc   +1 more source

Sprouty Proteins Are Targeted to Membrane Ruffles upon Growth Factor Receptor Tyrosine Kinase Activation [PDF]

, 2000
Jormay Lim, Esther Sook Miin Wong, Siew Hwa Ong, Permeen Yusoff, Boon Chuan Low, Graeme R. Guy   +5 more
openalex   +1 more source

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

Cell, 1992
E. Lowenstein, R. Daly, A. Batzer, W. Li, B. Margolis, Richard L. Lammers, A. Ullrich, E. Skolnik, D. Bar-Sagi, J. Schlessinger   +9 more
semanticscholar   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Innovative Approaches in Cancer Treatment: Emphasizing the Role of Nanomaterials in Tyrosine Kinase Inhibition. [PDF]

Pharmaceutics
Kurillová A, Kvítek L, Panáček A.
europepmc   +1 more source