Results 1 to 10 of about 9,917 (101)

Spatiotemporal Organization of PTK7 Diffusion on Cell Surface Facilitates Tumor Invasion and Migration [PDF]

Advanced Science
The spatiotemporal dynamics of protein kinase diffusion govern signal activation cascades, thereby modulating fundamental cellular functions. Pseudokinases, catalytically inactive members of the protein kinase superfamily, utilize noncatalytic signaling ...
Yaohua Li, Tao Pan, Yu Wang, Sainan Guo, Daiquan Chen, Liu Liu, Liwei Wang, Yang Sun, Weihong Tan   +8 more
doaj   +2 more sources

Prognostic Role of Receptor Tyrosine Kinase-Like Orphan Receptors in Intestinal-Type Gastric Cancer. [PDF]

Asian Pac J Cancer Prev, 2021
Nema R, Patel P, Kumar A.
europepmc   +2 more sources

Upregulation of receptor tyrosine kinase-like orphan receptor 2 in idiopathic pulmonary fibrosis [PDF]

The Korean Journal of Internal Medicine, 2021
Background/Aims Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a major regulator of Wnt signaling, which is involved in fibroblast dysfunction.
Ji-Hye Son, Jong-Uk Lee, Susie Chin, Eun-Suk Go, Jai-Seong Park, Hwa-Kyun Shin, Hun Soo Chang, Jong-Sook Park, Choon-Sik Park   +8 more
doaj   +1 more source

Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. [PDF]

PLoS ONE, 2014
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the receptor tyrosine kinase (RTK) family and have been associated with several human diseases.
Travis W Bainbridge, Venita I DeAlmeida, Anita Izrael-Tomasevic, Cécile Chalouni, Borlan Pan, Joshua Goldsmith, Alia P Schoen, Gabriel A Quiñones, Ryan Kelly, Jennie R Lill, Wendy Sandoval, Mike Costa, Paul Polakis, David Arnott, Bonnee Rubinfeld, James A Ernst   +15 more
doaj   +1 more source

Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations. [PDF]

PLoS ONE, 2015
T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often accompanied by a loss of normal CD19+ B cells and humoral immunity.
Drew C Deniger, Jianqiang Yu, M Helen Huls, Matthew J Figliola, Tiejuan Mi, Sourindra N Maiti, George F Widhopf, Lenka V Hurton, Radhika Thokala, Harjeet Singh, Simon Olivares, Richard E Champlin, William G Wierda, Thomas J Kipps, Laurence J N Cooper   +14 more
doaj   +1 more source

The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention

Cells, 2021
The WNT pathway is one of the major signaling cascades frequently deregulated in human cancer. While research had initially focused on signal transduction centered on β-catenin as a key effector activating a pro-tumorigenic transcriptional response ...
Kerstin Menck, Saskia Heinrichs, Cornelia Baden, Annalen Bleckmann   +3 more
doaj   +1 more source

A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information. [PDF]

PLoS ONE, 2008
The insulin receptor (IR), the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor-related receptor (IRR) are covalently-linked homodimers made up of several structural domains.
Miguel E Rentería, Neha S Gandhi, Pablo Vinuesa, Erik Helmerhorst, Ricardo L Mancera   +4 more
doaj   +1 more source

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background A hallmark of heart failure is cardiac fibrosis, which results from the injury‐induced differentiation response of resident fibroblasts to myofibroblasts that deposit extracellular matrix.
Nicholas W. Chavkin, Soichi Sano, Ying Wang, Kosei Oshima, Hayato Ogawa, Keita Horitani, Miho Sano, Susan MacLauchlan, Anders Nelson, Karishma Setia, Tanvi Vippa, Yosuke Watanabe, Jeffrey J. Saucerman, Karen K. Hirschi, Noyan Gokce, Kenneth Walsh   +15 more
doaj   +1 more source

Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine. [PDF]

PLoS ONE, 2014
BACKGROUND AND AIMS:Amphibian intestinal remodeling, where thyroid hormone (T3) induces some larval epithelial cells to become adult stem cells analogous to the mammalian intestinal ones, serves as a unique model for studying how the adult stem cells are
Atsuko Ishizuya-Oka, Mitsuko Kajita, Takashi Hasebe   +2 more
doaj   +1 more source

Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression

Cell Communication and Signaling, 2023
Background Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment.
Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann, Kerstin Menck   +13 more
doaj   +1 more source